Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two...

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Bibliographic Details
Main Authors: Maier, M.S., Roccatagliata, A.J., Kuriss, A., Chludil, H., Seldes, A.M., Pujol, C.A., Damonte, E.B.
Format: Journal/Newspaper
Language:unknown
Subjects:
antivirus agent
liouvilloside A
liouvilloside B
triterpene derivative
unclassified drug
antiviral activity
article
cytostasis
cytotoxicity
drug isolation
echinoderm
Herpes simplex virus 1
immunomodulation
structure analysis
sulfation
Animals
Antineoplastic Agents
Antiviral Agents
Carbohydrate Conformation
Cercopithecus aethiops
Drug Screening Assays
Antitumor
Herpesvirus 1
Human
Hydrolysis
Magnetic Resonance Spectroscopy
Methylation
Microbial Sensitivity Tests
Oligosaccharides
Sea Cucumbers
Spectrometry
Mass
Fast Atom Bombardment
Triterpenes
Vero Cells
Antarc*
Antarctic
Online Access:https://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier
Description
Summary:Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL.

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