New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii

• Main Authors: Roccatagliata, Alejandro Jorge, Maier, Marta Silvia, Seldes, Alicia Marta
• Language: unknown
• Published: 1998
• Subjects: 5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate; cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate; cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate; cholesterol; hydroxysteroid; sterol; unclassified drug; article; chemical analysis; column chromatography; data analysis; drug isolation; enzyme activity; high performance liquid chromatography; nuclear magnetic resonance; sulfation; Astrotoma agassizii; Antarctic; Argentina; The Antarctic; Antarc*
• Online Access: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n3_p370_Roccatagliata; https://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p370_Roccatagliata

Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids were established from spectral and chemical correlations with related steroids as (20R)-cholesta-5,24-diene-2β,3α,21-triol 2,21-disulfate (1), (20R)-5α-cholest-24-ene-2β,3α,21-triol 3,21-disulfate (3), and (20R)- cholesta-5,24-diene-2α,3α,4β,21-tetrol 3,21-disulfate (5). Analysis of the nonsulfated sterol fraction has shown the presence of cholest-5-en-3β-ol, cholesta-5,24-dien-3β-ol and (22E) cholesta-5,22-dien-3β-ol as the major sterols. Fil:Roccatagliata, A.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maier, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.