Lipase-catalyzed mono-O-acylation of dithiothreitol and dithioerythritol

Mono-O-acyl derivatives of dithiothreitol and dithioerythritol were obtained in 40-60% yield, through a lipase-catalyzed transesterification in organic media. Reactions were conducted in neutral conditions at moderate temperature, with or without solvent. Candida antarctica lipase resulted the most...

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Bibliographic Details
Main Authors: Iglesias, Luis Emilio, Baldessari, Alicia, Gros, Eduardo Gervasio
Language:unknown
Published: 1998
Subjects:
dithioerythritol
dithiothreitol
solvent
triacylglycerol lipase
acylation
article
candida
temperature
Argentina
Antarc*
Antarctica
Online Access:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v20_n3_p275_Iglesias
https://hdl.handle.net/20.500.12110/paper_01415492_v20_n3_p275_Iglesias
Description
Summary:Mono-O-acyl derivatives of dithiothreitol and dithioerythritol were obtained in 40-60% yield, through a lipase-catalyzed transesterification in organic media. Reactions were conducted in neutral conditions at moderate temperature, with or without solvent. Candida antarctica lipase resulted the most efficient biocatalyst (yields over 60%) when working without solvent. Fil:Iglesias, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baldessari, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.

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