Update on CDV strains of Arctic-like lineage detected from dogs in Italy

Canine distemper virus (CDV) is the etiologic agent of distemper in dogs. It exhibits an elevated potential of crossing species barriers, infecting a wide range of wild and domestic carnivores. Of its encoding genes, hemagglutinin (H) shows high heterogeneity, and it was used to determine the relati...

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Bibliographic Details
Main Authors: Mira F, Purpari G, Di Bella S, Vicari D, Schirò G, Di Marco P, Macaluso G, Battilani M, Guercio A.
Other Authors: Mira F, Purpari G, Di Bella S, Vicari D, Schirò G, Di Marco P, Macaluso G, Battilani M, Guercio A.
Format: Article in Journal/Newspaper
Language:English
Published: 2018
Subjects:
Biological evolution
Canine distemper viru
Dog
Europe
Genomic
Hemagglutinin
Arctic
Online Access:http://hdl.handle.net/11585/662222
https://doi.org/10.12834/VetIt.1455.7862.2
http://www.izs.it/vet_italiana/2018/54_3/VetIt_1455_7862_2.pdf
Description
Summary:Canine distemper virus (CDV) is the etiologic agent of distemper in dogs. It exhibits an elevated potential of crossing species barriers, infecting a wide range of wild and domestic carnivores. Of its encoding genes, hemagglutinin (H) shows high heterogeneity, and it was used to determine the relationship between CDV strains due to its variability and key role in determining cell tropism, host shift, and in eliciting a protective immune response. This study analysed the full-length H gene sequence of Arctic-like CDV strains collected from dogs in Italy during a period in which an increased activity of CDV diffusion was observed. The common amino acid changes and features of Arctic-like CDV strains collected from 2011 to 2016 in Europe were described, providing an updated analysis of the genomic features. A comparison with CDV vaccine strains was carried out to evaluate the increased genomic difference with CDV Arctic-like field strains. This study provides a complete and updated analysis of the current spreading strains of Arctic-like lineage and the main amino acid variations in the hemagglutinin gene sequence circulating in Italy. Moreover, it provides novel information regarding the evolution of the most recent CDV Arctic-like lineage strains collected in Europe.

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