Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland

• Published in: Reproductive Toxicology
• Main Authors: Kvist, Linus, Giwercman, Yvonne Lundberg, Jönsson, Bo A G, Lindh, Christian H, Bonde, Jens Peter, Toft, Gunnar, Strucinski, Pawel, Pedersen, Henning Sloth, Zvyezday, Valentyna, Giwercman, Aleksander
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2012
• Subjects: Greenland; inuit
• Online Access: https://pure.au.dk/portal/da/publications/serum-levels-of-perfluorinated-compounds-and-sperm-yx-chromosome-ratio-in-two-european-populations-and-in-inuit-from-greenland(f21720c9-3878-446d-a022-85fdef2efda7).html; https://doi.org/10.1016/j.reprotox.2012.09.007

This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.