Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU:protocol for a randomised controlled trial

Transfusion of red blood cells (RBC) is recommended in septic shock and the majority of these patients receive RBC transfusion in the intensive care unit (ICU). However, benefit and harm of RBCs have not been established in this group of high-risk patients.

Bibliographic Details
Published in:Trials
Main Authors: Holst, Lars B, Haase, Nicolai, Wetterslev, Jørn, Wernerman, Jan, Aneman, Anders, Guttormsen, Anne B, Johansson, Pär I, Karlsson, Sari, Klemenzson, Gudmundur, Winding, Robert, Nebrich, Lars, Albeck, Carsten, Vang, Marianne L, Bülow, Hans-Henrik, Elkjær, Jeanie M, Nielsen, Jane S, Kirkegaard, Peter, Nibro, Helle, Lindhardt, Anne, Strange, Ditte Gry, Thormar, Katrin, Poulsen, Lone M, Berezowicz, Pawel, Bådstøløkken, Per Martin, Strand, Kristian, Cronhjort, Maria, Haunstrup, Elsebeth, Rian, Omar, Oldner, Anders, Bendtsen, Asger Ole, Iversen, Susanne, Langva, Jørn-Åge, Johansen, Rasmus Bøgh, Nielsen, Niklas, Pettilä, Ville, Reinikainen, Matti, Keld, Dorte, Leivdal, Siv, Breider, Jan-Michael, Tjäder, Inga, Reiter, Nanna, Gøttrup, Ulf, White, Jonathan Oliver, Wiis, Jørgen, Andersen, Lasse Høgh, Steensen, Morten, Perner, Anders
Format: Article in Journal/Newspaper
Language:English
Published: 2013
Subjects:
Biological Markers
Clinical Protocols
Clinical Trials Data Monitoring Committees
Erythrocyte Transfusion
Fluid Therapy
Hemoglobins
Humans
Iceland
Intensive Care Units
Research Design
Risk Assessment
Risk Factors
Scandinavia
Shock
Septic
Time Factors
Treatment Outcome
Online Access:https://pure.au.dk/portal/da/publications/transfusion-requirements-in-septic-shock-triss-trial--comparing-the-effects-and-safety-of-liberal-versus-restrictive-red-blood-cell-transfusion-in-septic-shock-patients-in-the-icu(e533e9b8-178e-47d7-8ae9-b6408baaffef).html
https://doi.org/10.1186/1745-6215-14-150
Description
Summary:Transfusion of red blood cells (RBC) is recommended in septic shock and the majority of these patients receive RBC transfusion in the intensive care unit (ICU). However, benefit and harm of RBCs have not been established in this group of high-risk patients.

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