Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions

Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and con...

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Bibliographic Details
Published in:Reproductive Toxicology
Main Authors: Specht, Ina Olmer, Hougaard, Karin, Spanò, Marcello, Bizzaro, Davide, Manicardi, Gian Carlo, Lindh, Christian H, Toft, Gunnar, Jönsson, Bo A G, Giwercman, Aleksander, Bonde, Jens Peter E
Format: Article in Journal/Newspaper
Language:English
Published: 2012
Subjects:
Adult
Apoptosis
Biological Markers
Chromatin
DNA Damage
DNA Fragmentation
Environmental Monitoring
Environmental Pollutants
Female
Fluorocarbons
Greenland
Humans
In Situ Nick-End Labeling
Male
Middle Aged
Poland
Pregnancy
Reproduction
Spermatozoa
Spouses
Ukraine
Young Adult
Online Access:https://pure.au.dk/portal/da/publications/sperm-dna-integrity-in-relation-to-exposure-to-environmental-perfluoroalkyl-substances--a-study-of-spouses-of-pregnant-women-in-three-geographical-regions(386a50c2-431f-4a81-b3ce-370d1db0c8e2).html
https://doi.org/10.1016/j.reprotox.2012.02.008
Description
Summary:Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.

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