Characterization of the genetic profile of five Danish dog breeds
This investigation presents results from a genetic characterization of five Danish dog breeds genotyped on the CanineHD BeadChip microarray with 170K SNPs. The breeds investigated were 1) Danish Spitz (DS, n = 8), 2) Danish-Swedish farm Dog (DSF n = 18), 3) Broholmer (B, n = 22), 4) Old Danish Point...
Published in: | Journal of Animal Science |
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Online Access: | https://pure.au.dk/portal/da/publications/characterization-of-the-genetic-profile-of-five-danish-dog-breeds(33901f0d-8b2c-4398-b1c9-111fa0a2c53b).html https://doi.org/10.2527/jas.2013-6617 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/33901f0d-8b2c-4398-b1c9-111fa0a2c53b 2023-05-15T16:28:14+02:00 Characterization of the genetic profile of five Danish dog breeds Pertoldi, Cino Kristensen, Torsten Nygaard Loeschcke, Volker Berg, Peer Praebel, Anne Stronen, Astrid Vik Proschowsky, Helle Friis Fredholm, Merete 2013-08-29 https://pure.au.dk/portal/da/publications/characterization-of-the-genetic-profile-of-five-danish-dog-breeds(33901f0d-8b2c-4398-b1c9-111fa0a2c53b).html https://doi.org/10.2527/jas.2013-6617 eng eng info:eu-repo/semantics/restrictedAccess Pertoldi , C , Kristensen , T N , Loeschcke , V , Berg , P , Praebel , A , Stronen , A V , Proschowsky , H F & Fredholm , M 2013 , ' Characterization of the genetic profile of five Danish dog breeds ' , Journal of Animal Science , vol. 91 , no. 11 , pp. 5122-5127 . https://doi.org/10.2527/jas.2013-6617 article 2013 ftuniaarhuspubl https://doi.org/10.2527/jas.2013-6617 2020-07-18T21:27:17Z This investigation presents results from a genetic characterization of five Danish dog breeds genotyped on the CanineHD BeadChip microarray with 170K SNPs. The breeds investigated were 1) Danish Spitz (DS, n = 8), 2) Danish-Swedish farm Dog (DSF n = 18), 3) Broholmer (B, n = 22), 4) Old Danish Pointing Dog (ODP, n = 24), and 5) Greenland Dog (GD, n = 23). The aims of the investigation were to characterize the genetic profile of the abovementioned dog breeds by quantifying the genetic differentiation among them and the degree of genetic homogeneity within breeds. The genetic profile was determined by means of principal component analysis (PCA) and through a Bayesian clustering method. Both the PCA and the Bayesian clustering method revealed a clear genetic separation of the five breeds. The level of genetic variation within the breeds varied. The expected heterozygosity (HE) as well as the degree of polymorphism (P%) ranked the dog breeds in the order: DS > DSF > B > ODP > GD. Interestingly, the breed with a tenfold higher census population size compared to the other breeds, the Greenland Dog, had the lowest within-breed genetic variation, emphasizing that census size is a poor predictor of genetic variation. The observed differences in variation among and within dog breeds may be related to factors such as genetic drift, founder effects, genetic admixture and population bottlenecks. We further examined whether the observed genetic patterns in the five dog breeds can be used to design breeding strategies for the preservation of the genetic pool of these dog breeds. Article in Journal/Newspaper Greenland Aarhus University: Research Greenland Journal of Animal Science 91 11 5122 5127 |
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Open Polar |
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Aarhus University: Research |
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ftuniaarhuspubl |
language |
English |
description |
This investigation presents results from a genetic characterization of five Danish dog breeds genotyped on the CanineHD BeadChip microarray with 170K SNPs. The breeds investigated were 1) Danish Spitz (DS, n = 8), 2) Danish-Swedish farm Dog (DSF n = 18), 3) Broholmer (B, n = 22), 4) Old Danish Pointing Dog (ODP, n = 24), and 5) Greenland Dog (GD, n = 23). The aims of the investigation were to characterize the genetic profile of the abovementioned dog breeds by quantifying the genetic differentiation among them and the degree of genetic homogeneity within breeds. The genetic profile was determined by means of principal component analysis (PCA) and through a Bayesian clustering method. Both the PCA and the Bayesian clustering method revealed a clear genetic separation of the five breeds. The level of genetic variation within the breeds varied. The expected heterozygosity (HE) as well as the degree of polymorphism (P%) ranked the dog breeds in the order: DS > DSF > B > ODP > GD. Interestingly, the breed with a tenfold higher census population size compared to the other breeds, the Greenland Dog, had the lowest within-breed genetic variation, emphasizing that census size is a poor predictor of genetic variation. The observed differences in variation among and within dog breeds may be related to factors such as genetic drift, founder effects, genetic admixture and population bottlenecks. We further examined whether the observed genetic patterns in the five dog breeds can be used to design breeding strategies for the preservation of the genetic pool of these dog breeds. |
format |
Article in Journal/Newspaper |
author |
Pertoldi, Cino Kristensen, Torsten Nygaard Loeschcke, Volker Berg, Peer Praebel, Anne Stronen, Astrid Vik Proschowsky, Helle Friis Fredholm, Merete |
spellingShingle |
Pertoldi, Cino Kristensen, Torsten Nygaard Loeschcke, Volker Berg, Peer Praebel, Anne Stronen, Astrid Vik Proschowsky, Helle Friis Fredholm, Merete Characterization of the genetic profile of five Danish dog breeds |
author_facet |
Pertoldi, Cino Kristensen, Torsten Nygaard Loeschcke, Volker Berg, Peer Praebel, Anne Stronen, Astrid Vik Proschowsky, Helle Friis Fredholm, Merete |
author_sort |
Pertoldi, Cino |
title |
Characterization of the genetic profile of five Danish dog breeds |
title_short |
Characterization of the genetic profile of five Danish dog breeds |
title_full |
Characterization of the genetic profile of five Danish dog breeds |
title_fullStr |
Characterization of the genetic profile of five Danish dog breeds |
title_full_unstemmed |
Characterization of the genetic profile of five Danish dog breeds |
title_sort |
characterization of the genetic profile of five danish dog breeds |
publishDate |
2013 |
url |
https://pure.au.dk/portal/da/publications/characterization-of-the-genetic-profile-of-five-danish-dog-breeds(33901f0d-8b2c-4398-b1c9-111fa0a2c53b).html https://doi.org/10.2527/jas.2013-6617 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Pertoldi , C , Kristensen , T N , Loeschcke , V , Berg , P , Praebel , A , Stronen , A V , Proschowsky , H F & Fredholm , M 2013 , ' Characterization of the genetic profile of five Danish dog breeds ' , Journal of Animal Science , vol. 91 , no. 11 , pp. 5122-5127 . https://doi.org/10.2527/jas.2013-6617 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.2527/jas.2013-6617 |
container_title |
Journal of Animal Science |
container_volume |
91 |
container_issue |
11 |
container_start_page |
5122 |
op_container_end_page |
5127 |
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1766017864367603712 |