A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany

Genome-wide linkage studies and genome-wide association studies have not as yet identified major genes contributing to primary hypertension in the general population. This state-of-affairs suggests considerable heterogeneity with small contributing effects for primary hypertension, or other complex...

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Bibliographic Details
Published in:Journal of Hypertension
Main Authors: Hoffmann, Katrin, Planitz, Christian, Rüschendorf, Franz, Müller-Myhsok, Bertram, Stassen, Hans H, Lucke, Barbara, Mattheisen, Manuel, Stumvoll, Michael, Bochmann, Rolf, Zschornack, Martin, Wienker, Thomas F, Nürnberg, Peter, Reis, André, Luft, Friedrich C, Lindner, Tom H
Format: Article in Journal/Newspaper
Language:English
Published: 2009
Subjects:
Adult
Aged
Chromosome Mapping
Chromosomes
Human
Pair 1
Female
Genetic Linkage
Genome-Wide Association Study
Germany
Humans
Hypertension
Lod Score
Male
Metabolic Syndrome X
Middle Aged
Multigene Family
Population Groups
Canada
Iceland
Online Access:https://pure.au.dk/portal/da/publications/a-novel-locus-for-arterial-hypertension-on-chromosome-1p36-maps-to-a-metabolic-syndrome-trait-cluster-in-the-sorbs-a-slavic-population-isolate-in-germany(031cc32b-e050-4420-b286-925a43e1602e).html
https://doi.org/10.1097/HJH.0b013e328328123d
Description
Summary:Genome-wide linkage studies and genome-wide association studies have not as yet identified major genes contributing to primary hypertension in the general population. This state-of-affairs suggests considerable heterogeneity with small contributing effects for primary hypertension, or other complex genetic traits, in outbred populations. Isolated populations, as recent data from Iceland and French Canada suggest, could offer a solution to this problem.

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