| Summary: | Изучено влияние фармакологической композиции на основе меланина на интенсивность перекисного окисления липидов (ПОЛ) в сыворотке крови при экспериментальной резаной ране. Результаты исследования показали положительное влияние фармакологической композиции на основе меланина на процессы свободнорадикального окисления и репаративной регенерации в условиях экспериментальной резаной раны. Показано, что использование меланина влияет на интенсивность процесов ПОЛ в крови, снижая количество первичных и вторичных продуктов и повышая активность ферментов антиоксидантной системы; Now it is considered, that melanin is promising for application in medicine and pharmacology. Study of wound-healing action was conducted on model of full-thickness skin wound. The efficiency of wounds treatment with Melanin that is produced by Antarctic black yeast-like fungi Nadsoniella nigra strain X1-M from vertical cliffs on the island Galindez (Antarctica) on the full-thickness skin wound model was studied. «Melanin-gel» (0.1% melanin dissolved in 0.5% carbopol) had antimicrobial property against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, that is one of the mechanisms of wound healing. Application of the «Melanin-gel» on wound area enhanced wound cleaning from dead tissue and reduced eschar, stimulated the early growth of granulation tissue, and improved epithelialization of the wound. Objective. The purpose of this paper is to study the indices of pro- and antioxydative system (contens of dienic conjugates, schiff bases, TBA-active products, activity of catalase and superoxyd dismutase) in blood serum during full-thickness skin wound healing without treatment and with application of new pharmaceutical composition based on melanin for rats with experimental wounds. Methods. Experiments conducted in accordance with international principles of the European Convention for the Protection of vertebrate animals used for experimental and other scientific purposes, according to the Law of Ukraine of 21.02.2006 № 3447-IV «On ...
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