Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias
Background: Prospective birth cohorts are essential for identifying associations between exposures and outcomes. However, voluntary participation introduces a potential bias due to self selection since the persons that chose to participate may differ in background characteristics and behaviors. Obje...
Published in: | The Journal of Maternal-Fetal & Neonatal Medicine |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Umeå universitet, Institutionen för odontologi
2022
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Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191186 https://doi.org/10.1080/14767058.2021.2011854 |
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Umeå University: Publications (DiVA) |
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language |
English |
topic |
enrollment bias NICE birth cohort pregnancy cohort self selection bias self-selection Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi |
spellingShingle |
enrollment bias NICE birth cohort pregnancy cohort self selection bias self-selection Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi Ögge, Linda Englund Murray, Fiona Modzelewska, Dominika Lundqvist, Robert Nilsson, Staffan Carré, Helena Kippler, Maria Wold, Agnes E. Sandberg, Ann-Sofie Sandin, Anna Jacobsson, Bo Barman, Malin Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias |
topic_facet |
enrollment bias NICE birth cohort pregnancy cohort self selection bias self-selection Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi |
description |
Background: Prospective birth cohorts are essential for identifying associations between exposures and outcomes. However, voluntary participation introduces a potential bias due to self selection since the persons that chose to participate may differ in background characteristics and behaviors. Objectives: To investigate potential bias due to self-selection in the Nutritional impact onImmunological maturation duringChildhood in relation to theEnvironment (NICE) birth cohort in northern Sweden. Methods: Women in the NICE birth cohort (N = 621) were compared to nonparticipating pregnant women in Norrbotten County in northern Sweden who were eligible for participation (N = 4976) regarding maternal characteristics and lifestyle. Maternal characteristics and pregnancy outcomes were compared between the groups and associations between exposures (smoking, folic acid, BMI, parity, education) and pregnancy outcomes (birth weight and gestational age) were analyzed by linear regression analyses, examining any interaction with the group. Results: NICE participants were more highly educated, older and more likely to cohabit than the non-participants. They more often took folic acid and multivitamin supplements and less often smoked during early pregnancy. Pregnancy outcomes (mode of delivery, gestational age at delivery, birth weight and APGAR score) did, however, not differ significantly between participants and non-participants. Smoking, BMI, education and parity affected gestational age and birth weight, but the associations were of similar magnitude in participants and non-participants, with no significant effect on the group. Conclusion: Self-selection to the NICE study was evident in some factors related to lifestyle and socioeconomic characteristics but did not appear to skew pregnancy outcomes or alter well-known effects of certain lifestyle parameters on pregnancy outcomes. |
format |
Article in Journal/Newspaper |
author |
Ögge, Linda Englund Murray, Fiona Modzelewska, Dominika Lundqvist, Robert Nilsson, Staffan Carré, Helena Kippler, Maria Wold, Agnes E. Sandberg, Ann-Sofie Sandin, Anna Jacobsson, Bo Barman, Malin |
author_facet |
Ögge, Linda Englund Murray, Fiona Modzelewska, Dominika Lundqvist, Robert Nilsson, Staffan Carré, Helena Kippler, Maria Wold, Agnes E. Sandberg, Ann-Sofie Sandin, Anna Jacobsson, Bo Barman, Malin |
author_sort |
Ögge, Linda Englund |
title |
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias |
title_short |
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias |
title_full |
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias |
title_fullStr |
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias |
title_full_unstemmed |
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias |
title_sort |
maternal characteristics and pregnancy outcomes in the nice birth cohort: an assessment of self-selection bias |
publisher |
Umeå universitet, Institutionen för odontologi |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191186 https://doi.org/10.1080/14767058.2021.2011854 |
genre |
Northern Sweden Norrbotten |
genre_facet |
Northern Sweden Norrbotten |
op_relation |
The Journal of Maternal-Fetal & Neonatal Medicine, 1476-7058, 2022, 35:25, s. 9014-9022 orcid:0000-0003-4059-3368 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191186 doi:10.1080/14767058.2021.2011854 PMID 34979877 ISI:000737651000001 Scopus 2-s2.0-85122232794 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/14767058.2021.2011854 |
container_title |
The Journal of Maternal-Fetal & Neonatal Medicine |
container_start_page |
1 |
op_container_end_page |
9 |
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1779318101688451072 |
spelling |
ftumeauniv:oai:DiVA.org:umu-191186 2023-10-09T21:54:31+02:00 Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias Ögge, Linda Englund Murray, Fiona Modzelewska, Dominika Lundqvist, Robert Nilsson, Staffan Carré, Helena Kippler, Maria Wold, Agnes E. Sandberg, Ann-Sofie Sandin, Anna Jacobsson, Bo Barman, Malin 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191186 https://doi.org/10.1080/14767058.2021.2011854 eng eng Umeå universitet, Institutionen för odontologi Umeå universitet, Avdelningen för medicin Umeå universitet, Obstetrik och gynekologi Umeå universitet, Pediatrik Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Obstetrics and Gynaecology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden; Department of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Sweden Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden The Journal of Maternal-Fetal & Neonatal Medicine, 1476-7058, 2022, 35:25, s. 9014-9022 orcid:0000-0003-4059-3368 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191186 doi:10.1080/14767058.2021.2011854 PMID 34979877 ISI:000737651000001 Scopus 2-s2.0-85122232794 info:eu-repo/semantics/openAccess enrollment bias NICE birth cohort pregnancy cohort self selection bias self-selection Obstetrics Gynecology and Reproductive Medicine Reproduktionsmedicin och gynekologi Article in journal info:eu-repo/semantics/article text 2022 ftumeauniv https://doi.org/10.1080/14767058.2021.2011854 2023-09-22T14:00:05Z Background: Prospective birth cohorts are essential for identifying associations between exposures and outcomes. However, voluntary participation introduces a potential bias due to self selection since the persons that chose to participate may differ in background characteristics and behaviors. Objectives: To investigate potential bias due to self-selection in the Nutritional impact onImmunological maturation duringChildhood in relation to theEnvironment (NICE) birth cohort in northern Sweden. Methods: Women in the NICE birth cohort (N = 621) were compared to nonparticipating pregnant women in Norrbotten County in northern Sweden who were eligible for participation (N = 4976) regarding maternal characteristics and lifestyle. Maternal characteristics and pregnancy outcomes were compared between the groups and associations between exposures (smoking, folic acid, BMI, parity, education) and pregnancy outcomes (birth weight and gestational age) were analyzed by linear regression analyses, examining any interaction with the group. Results: NICE participants were more highly educated, older and more likely to cohabit than the non-participants. They more often took folic acid and multivitamin supplements and less often smoked during early pregnancy. Pregnancy outcomes (mode of delivery, gestational age at delivery, birth weight and APGAR score) did, however, not differ significantly between participants and non-participants. Smoking, BMI, education and parity affected gestational age and birth weight, but the associations were of similar magnitude in participants and non-participants, with no significant effect on the group. Conclusion: Self-selection to the NICE study was evident in some factors related to lifestyle and socioeconomic characteristics but did not appear to skew pregnancy outcomes or alter well-known effects of certain lifestyle parameters on pregnancy outcomes. Article in Journal/Newspaper Northern Sweden Norrbotten Umeå University: Publications (DiVA) The Journal of Maternal-Fetal & Neonatal Medicine 1 9 |