Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three...

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Bibliographic Details
Published in:Animal Genetics
Main Authors: Baird, A. E G, Carter, S. D., Innes, J. F., Ollier, W., Short, A.
Format: Article in Journal/Newspaper
Language:English
Published: 2014
Subjects:
cranial cruciate ligament rupture
Newfoundlands
population stratification
Newfoundland
Online Access:https://research.manchester.ac.uk/en/publications/f5b07ad7-2bec-4fa9-865a-53d5043bce3a
https://doi.org/10.1111/age.12162
http://www.wiley.com/bw/journal.asp?ref=0268-9146
Description
Summary:Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR. © 2014 Stichting International Foundation for Animal Genetics.

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