PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism
The transcription factor, PPAR delta is involved in suppressing inflammation, stimulating oligodendroglial biogenesis and myelination. Furthermore, activation of PPAR delta directly protects mitochondria against noxious stimuli and stimulates biogenesis of new mitochondria. PPAR delta activation dir...
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ftumaastrichtcri:oai:cris.maastrichtuniversity.nl:publications/8ee283ff-21d5-4fed-8ef3-bb402e078ed3 2023-05-15T16:06:47+02:00 PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism Altinoz, Meric A. Ozpinar, Aysel 2019-04 https://cris.maastrichtuniversity.nl/en/publications/8ee283ff-21d5-4fed-8ef3-bb402e078ed3 https://doi.org/10.1016/j.intimp.2019.01.057 eng eng info:eu-repo/semantics/closedAccess Altinoz , M A & Ozpinar , A 2019 , ' PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism ' , International Immunopharmacology , vol. 69 , pp. 245-256 . https://doi.org/10.1016/j.intimp.2019.01.057 Erucic acid PPAR-delta Multiple sclerosis Alzheimer's Disease Neuroprotection Remyelination PROLIFERATOR-ACTIVATED RECEPTOR CENTRAL-NERVOUS-SYSTEM X-LINKED ADRENOLEUKODYSTROPHY LORENZOS OIL COGNITIVE IMPAIRMENT BRASSICA-JUNCEA CELLS BRAIN EXPRESSION MACROPHAGES article 2019 ftumaastrichtcri https://doi.org/10.1016/j.intimp.2019.01.057 2022-07-19T09:11:29Z The transcription factor, PPAR delta is involved in suppressing inflammation, stimulating oligodendroglial biogenesis and myelination. Furthermore, activation of PPAR delta directly protects mitochondria against noxious stimuli and stimulates biogenesis of new mitochondria. PPAR delta activation directly inhibits neuronal cell death and reduces both the level and neurotoxicity of Amyloid-beta fibers in Alzheimer's Disease (AD) models. Among the important ligands of PPAR delta is erucic acid (EA, 22:1 n9), an edible omega-9 fatty acid and a component of Lorenzo's oil, which is used in the treatment of adrenoleukodystrophy (ALD). Nonetheless, the feature of PPAR delta-erucic acid interaction has not been extensively studied. EA can also be converted to nervonic acid, an important component of myelin. Hence, EA may act as an anti-inflammatory and remyelinating agent, which might be important in the management of another demyelinating disease, multiple sclerosis (MS). Oxidative injury and mitochondrial damage are among the features of ALD. Direct inhibitory effects of EA was observed on lipid peroxidation and inflammatory enzymes, neutrophil elastase and thrombin. EA also induces catalase, a potent antioxidant peroxisomal enzyme. However, EA is claimed to be a cardiotoxic molecule, yet these studies were mostly performed on rats, which do not efficiently metabolize EA. Further, EA is largely consumed by Asian population and Greenland Eskimos with no signs of cardiac damage. In this review, we shed light on the potential theraputic role of EA in MS and AD by blocking neural cell death, mitigating neuroinflammation and/or inducing myelination. Article in Journal/Newspaper eskimo* Greenland Maastricht University Research Publications Greenland International Immunopharmacology 69 245 256 |
institution |
Open Polar |
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Maastricht University Research Publications |
op_collection_id |
ftumaastrichtcri |
language |
English |
topic |
Erucic acid PPAR-delta Multiple sclerosis Alzheimer's Disease Neuroprotection Remyelination PROLIFERATOR-ACTIVATED RECEPTOR CENTRAL-NERVOUS-SYSTEM X-LINKED ADRENOLEUKODYSTROPHY LORENZOS OIL COGNITIVE IMPAIRMENT BRASSICA-JUNCEA CELLS BRAIN EXPRESSION MACROPHAGES |
spellingShingle |
Erucic acid PPAR-delta Multiple sclerosis Alzheimer's Disease Neuroprotection Remyelination PROLIFERATOR-ACTIVATED RECEPTOR CENTRAL-NERVOUS-SYSTEM X-LINKED ADRENOLEUKODYSTROPHY LORENZOS OIL COGNITIVE IMPAIRMENT BRASSICA-JUNCEA CELLS BRAIN EXPRESSION MACROPHAGES Altinoz, Meric A. Ozpinar, Aysel PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism |
topic_facet |
Erucic acid PPAR-delta Multiple sclerosis Alzheimer's Disease Neuroprotection Remyelination PROLIFERATOR-ACTIVATED RECEPTOR CENTRAL-NERVOUS-SYSTEM X-LINKED ADRENOLEUKODYSTROPHY LORENZOS OIL COGNITIVE IMPAIRMENT BRASSICA-JUNCEA CELLS BRAIN EXPRESSION MACROPHAGES |
description |
The transcription factor, PPAR delta is involved in suppressing inflammation, stimulating oligodendroglial biogenesis and myelination. Furthermore, activation of PPAR delta directly protects mitochondria against noxious stimuli and stimulates biogenesis of new mitochondria. PPAR delta activation directly inhibits neuronal cell death and reduces both the level and neurotoxicity of Amyloid-beta fibers in Alzheimer's Disease (AD) models. Among the important ligands of PPAR delta is erucic acid (EA, 22:1 n9), an edible omega-9 fatty acid and a component of Lorenzo's oil, which is used in the treatment of adrenoleukodystrophy (ALD). Nonetheless, the feature of PPAR delta-erucic acid interaction has not been extensively studied. EA can also be converted to nervonic acid, an important component of myelin. Hence, EA may act as an anti-inflammatory and remyelinating agent, which might be important in the management of another demyelinating disease, multiple sclerosis (MS). Oxidative injury and mitochondrial damage are among the features of ALD. Direct inhibitory effects of EA was observed on lipid peroxidation and inflammatory enzymes, neutrophil elastase and thrombin. EA also induces catalase, a potent antioxidant peroxisomal enzyme. However, EA is claimed to be a cardiotoxic molecule, yet these studies were mostly performed on rats, which do not efficiently metabolize EA. Further, EA is largely consumed by Asian population and Greenland Eskimos with no signs of cardiac damage. In this review, we shed light on the potential theraputic role of EA in MS and AD by blocking neural cell death, mitigating neuroinflammation and/or inducing myelination. |
format |
Article in Journal/Newspaper |
author |
Altinoz, Meric A. Ozpinar, Aysel |
author_facet |
Altinoz, Meric A. Ozpinar, Aysel |
author_sort |
Altinoz, Meric A. |
title |
PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism |
title_short |
PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism |
title_full |
PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism |
title_fullStr |
PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism |
title_full_unstemmed |
PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism |
title_sort |
ppar-δ and erucic acid in multiple sclerosis and alzheimer's disease. likely benefits in terms of immunity and metabolism |
publishDate |
2019 |
url |
https://cris.maastrichtuniversity.nl/en/publications/8ee283ff-21d5-4fed-8ef3-bb402e078ed3 https://doi.org/10.1016/j.intimp.2019.01.057 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
Altinoz , M A & Ozpinar , A 2019 , ' PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism ' , International Immunopharmacology , vol. 69 , pp. 245-256 . https://doi.org/10.1016/j.intimp.2019.01.057 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.intimp.2019.01.057 |
container_title |
International Immunopharmacology |
container_volume |
69 |
container_start_page |
245 |
op_container_end_page |
256 |
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1766402802323554304 |