Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer's Disease and Dementia : Results from the Betula Cohort in Northern Sweden

Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust...

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Bibliographic Details
Published in:Journal of Alzheimer's Disease
Main Authors: Aström, Daniel Oudin, Adolfsson, Rolf, Segersson, David, Forsberg, Bertil, Oudin, Anna
Format: Article in Journal/Newspaper
Language:English
Published: IOS Press 2021
Subjects:
Environmental Health and Occupational Health
Air pollution
Alzheimer's disease
dementia
particulate air pollution
PM
Northern Sweden
Online Access:https://lup.lub.lu.se/record/9f4758c7-29f9-4de1-b5ee-01a67a544c22
https://doi.org/10.3233/JAD-201538
Description
Summary:Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1µg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.

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