Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.
The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. A...
Published in: | Acta Neuropathologica Communications |
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Language: | English |
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BioMed Central (BMC)
2014
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Online Access: | https://lup.lub.lu.se/record/4334865 https://doi.org/10.1186/2051-5960-2-17 https://portal.research.lu.se/files/3999700/4628817.pdf |
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ftulundlup:oai:lup.lub.lu.se:5960839c-f801-46e3-be52-d77427233dba 2023-05-15T14:50:45+02:00 Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. George, Sonia Rönnbäck, Annica Gouras, Gunnar Petit, Géraldine Grueninger, Fiona Winblad, Bengt Graff, Caroline Brundin, Patrik 2014 application/pdf https://lup.lub.lu.se/record/4334865 https://doi.org/10.1186/2051-5960-2-17 https://portal.research.lu.se/files/3999700/4628817.pdf eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/4334865 http://dx.doi.org/10.1186/2051-5960-2-17 https://portal.research.lu.se/files/3999700/4628817.pdf pmid:24517102 scopus:84921298275 wos:000422389300017 info:eu-repo/semantics/openAccess Acta Neuropathologica Communications; 2(1), no 17 (2014) ISSN: 2051-5960 Neurosciences contributiontojournal/article info:eu-repo/semantics/article text 2014 ftulundlup https://doi.org/10.1186/2051-5960-2-17 2023-02-01T23:26:42Z The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry. Article in Journal/Newspaper Arctic Lund University Publications (LUP) Arctic Acta Neuropathologica Communications 2 1 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Neurosciences |
spellingShingle |
Neurosciences George, Sonia Rönnbäck, Annica Gouras, Gunnar Petit, Géraldine Grueninger, Fiona Winblad, Bengt Graff, Caroline Brundin, Patrik Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. |
topic_facet |
Neurosciences |
description |
The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry. |
format |
Article in Journal/Newspaper |
author |
George, Sonia Rönnbäck, Annica Gouras, Gunnar Petit, Géraldine Grueninger, Fiona Winblad, Bengt Graff, Caroline Brundin, Patrik |
author_facet |
George, Sonia Rönnbäck, Annica Gouras, Gunnar Petit, Géraldine Grueninger, Fiona Winblad, Bengt Graff, Caroline Brundin, Patrik |
author_sort |
George, Sonia |
title |
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. |
title_short |
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. |
title_full |
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. |
title_fullStr |
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. |
title_full_unstemmed |
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. |
title_sort |
lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of alzheimer's disease. |
publisher |
BioMed Central (BMC) |
publishDate |
2014 |
url |
https://lup.lub.lu.se/record/4334865 https://doi.org/10.1186/2051-5960-2-17 https://portal.research.lu.se/files/3999700/4628817.pdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Acta Neuropathologica Communications; 2(1), no 17 (2014) ISSN: 2051-5960 |
op_relation |
https://lup.lub.lu.se/record/4334865 http://dx.doi.org/10.1186/2051-5960-2-17 https://portal.research.lu.se/files/3999700/4628817.pdf pmid:24517102 scopus:84921298275 wos:000422389300017 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/2051-5960-2-17 |
container_title |
Acta Neuropathologica Communications |
container_volume |
2 |
container_issue |
1 |
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