Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. A...

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Bibliographic Details
Published in:Acta Neuropathologica Communications
Main Authors: George, Sonia, Rönnbäck, Annica, Gouras, Gunnar, Petit, Géraldine, Grueninger, Fiona, Winblad, Bengt, Graff, Caroline, Brundin, Patrik
Format: Article in Journal/Newspaper
Language:English
Published: BioMed Central (BMC) 2014
Subjects:
Neurosciences
Arctic
Online Access:https://lup.lub.lu.se/record/4334865
https://doi.org/10.1186/2051-5960-2-17
https://portal.research.lu.se/files/3999700/4628817.pdf
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Summary:The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.

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