Lipase-catalyzed synthesis of glycerol carbonate from renewable glycerol and dimethyl carbonate through transesterification

Glycerol carbonate is a key multifunctional compound employed as solvent, additive, monomer, and chemical intermediate. Enzymatic synthesis of glycerol carbonate from renewable starting materials (glycerol and dimethyl carbonate) was successfully achieved by-immobilized lipase from Candida antarctic...

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Bibliographic Details
Published in:Journal of Molecular Catalysis B: Enzymatic
Main Authors: Kim, Sang Cheol, Kim, Yong Hwan, Lee, Hyuk, Yoon, Do Young, Song, Bong Keun
Format: Article in Journal/Newspaper
Language:English
Published: ELSEVIER SCIENCE BV 2016
Subjects:
Candida antarctica
Glycerol
Glycerol carbonate
Lipase
Antarc*
Antarctica
Online Access:https://scholarworks.unist.ac.kr/handle/201301/20395
http://www.sciencedirect.com/science/article/pii/S1381117707001622
https://doi.org/10.1016/j.molcatb.2007.08.007
Description
Summary:Glycerol carbonate is a key multifunctional compound employed as solvent, additive, monomer, and chemical intermediate. Enzymatic synthesis of glycerol carbonate from renewable starting materials (glycerol and dimethyl carbonate) was successfully achieved by-immobilized lipase from Candida antarctica (CALB, Novozym 435). Addition of molecular sieves as scavenger for the removal of methanol, which was generated from dimethyl carbonate during the reaction, accelerated a reaction rate. After the optimization, the equimolar use of glycerol and dimethyl carbonate in the Novozym 435-catalyzed reaction yielded a glycerol carbonate with almost quantitative yield. The resulting glycerol carbonate from 60 degrees C reaction has shown the low enantiomeric excess (13% ee) as configuration of (R)-enantiomer. close

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