Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023

Group A Streptococcus isolates of the recently described M1UK clade have emerged to cause human infections in several European countries and elsewhere. Full-genome sequence analysis of M1 isolates discovered a close genomic relationship between some isolates from Scotland and the majority of isolate...

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Bibliographic Details
Published in:Eurosurveillance
Main Authors: Beres, Stephen B., Olsen, Randall J., Long, S. Wesley, Langley, Ross, Williams, Thomas, Erlendsdottir, Helga, Smith, Andrew, Kristinsson, Karl G., Musser, James M.
Format: Article in Journal/Newspaper
Language:English
Published: European Centre for Disease Control and Prevention (ECDC) 2024
Subjects:
Iceland
Online Access:https://eprints.gla.ac.uk/324167/
https://eprints.gla.ac.uk/324167/1/324167.pdf
Description
Summary:Group A Streptococcus isolates of the recently described M1UK clade have emerged to cause human infections in several European countries and elsewhere. Full-genome sequence analysis of M1 isolates discovered a close genomic relationship between some isolates from Scotland and the majority of isolates from Iceland causing serious infections in 2022 and 2023. Phylogenetic analysis strongly suggests that an isolate from or related to Scotland was the precursor to an M1UK variant responsible for almost all recent M1 infections in Iceland.

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