Expression and localization in the fish retina of a homologue of the Alzheimer's related PS1 gene

EARLY-ONSET familial Alzheimer's disease (early-onset FAD) has been linked with mutations in the presenilin gene, PS1. Mutations in PS1 may affect the processing/ trafficking of beta-amyloid precursor-protein (beta APP) and favour the production of toxic amyloid-beta fragments that are associat...

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Bibliographic Details
Main Authors: Archer, S, Hirano, J, Diss, JKJ, Fraser, SP, Djamgoz, MBA
Format: Article in Journal/Newspaper
Language:unknown
Published: LIPPINCOTT WILLIAMS & WILKINS 1998
Subjects:
Alzheimer's disease
Anguilla anguilla
carp
Cyprinus carpio
eel
PS1
rat
Rattus norvegicus
retina
vision
AMYLOID PRECURSOR PROTEIN
PRESENILIN-1 MUTATION
MISSENSE MUTATIONS
DISEASE
CELLS
LOCUS
Wilkins
Online Access:http://discovery.ucl.ac.uk/98898/
Description
Summary:EARLY-ONSET familial Alzheimer's disease (early-onset FAD) has been linked with mutations in the presenilin gene, PS1. Mutations in PS1 may affect the processing/ trafficking of beta-amyloid precursor-protein (beta APP) and favour the production of toxic amyloid-beta fragments that are associated with neural degeneration. This study reports the expression of a PS1-like cDNA in the carp (Cyprinus carpio) retina (the encoded protein shows 76% identity to the human PS1 protein). Carp PS1 mRNA was localized by in situ hybridization to the photoreceptor cell, inner nuclear and ganglion cell layers. Expression of the PS1 gene in the rat retina was also confirmed. The retinal expression of PS1 raises the possibility that PS1 mutations also lead to neural degeneration in the retina. NeuroReport 9: 3115-3122 (C) 1998 Lippincott Williams & Wilkins.

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