Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease

• Main Authors: Nioi, P, Sigurdsson, A, Thorleifsson, G, Helgason, H, Agustsdottir, AB, Norddahl, GL, Helgadottir, A, Magnusdottir, A, Jonasdottir, A, Gretarsdottir, S, Jonsdottir, I, Steinthorsdottir, V, Rafnar, T, Swinkels, DW, Galesloot, TE, Grarup, N, Jørgensen, T, Vestergaard, H, Hansen, T, Lauritzen, T, Linneberg, A, Friedrich, N, Krarup, NT, Fenger, M, Abildgaard, U, Hansen, PR, Galløe, AM, Braund, PS, Nelson, CP, Hall, AS, Williams, MJ, van Rij, AM, Jones, GT, Patel, RS, Levey, AI, Hayek, S, Shah, SH, Reilly, M, Eyjolfsson, GI, Sigurdardottir, O, Olafsson, I, Kiemeney, LA, Quyyumi, AA, Rader, DJ, Kraus, WE, Samani, NJ, Pedersen, O, Thorgeirsson, G, Masson, G, Holm, H, Gudbjartsson, D, Sulem, P, Thorsteinsdottir, U, Stefansson, K
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2016
• Subjects: Adult; Aged; 80 and over; Asialoglycoprotein Receptor; Base Sequence; Cholesterol; Coronary Artery Disease; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Haploinsufficiency; Humans; Iceland; Kaplan-Meier Estimate; Male; Middle Aged; Molecular Sequence Data; Myocardial Infarction; Risk; Sequence Analysis; DNA; Meier
• Online Access: https://discovery.ucl.ac.uk/id/eprint/1496167/1/patel_nejmoa1508419.pdf; https://discovery.ucl.ac.uk/id/eprint/1496167/

BACKGROUND: Several sequence variants are known to have effects on serum levels of non-high-density lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. METHODS: We sequenced the genomes of 2636 Icelanders and found variants that we then imputed into the genomes of approxima...