Greenlandic Inuit show genetic signatures of diet and climate adaptation.
The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for sig...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:1487325 2023-05-15T14:56:16+02:00 Greenlandic Inuit show genetic signatures of diet and climate adaptation. Fumagalli, M Moltke, I Grarup, N Racimo, F Bjerregaard, P Jørgensen, ME Korneliussen, TS Gerbault, P Skotte, L Linneberg, A Christensen, C Brandslund, I Jørgensen, T Huerta-Sánchez, E Schmidt, EB Pedersen, O Hansen, T Albrechtsen, A Nielsen, R 2015-09-18 http://discovery.ucl.ac.uk/1487325/ unknown Science , 349 (6254) pp. 1343-1347. (2015) Acclimatization Alleles Arctic Regions Body Height Body Weight Chromosomes Human Pair 11 Climate Diet High-Fat Fatty Acids Omega-3 Female Genetic Loci Genome Genome-Wide Association Study Greenland Humans Inuits Linkage Disequilibrium Male Membrane Lipids Polymorphism Single Nucleotide Selection Genetic Article 2015 ftucl 2016-05-05T22:16:02Z The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs. Article in Journal/Newspaper Arctic Greenland greenlandic inuit inuits University College London: UCL Discovery Arctic Greenland |
institution |
Open Polar |
collection |
University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
unknown |
topic |
Acclimatization Alleles Arctic Regions Body Height Body Weight Chromosomes Human Pair 11 Climate Diet High-Fat Fatty Acids Omega-3 Female Genetic Loci Genome Genome-Wide Association Study Greenland Humans Inuits Linkage Disequilibrium Male Membrane Lipids Polymorphism Single Nucleotide Selection Genetic |
spellingShingle |
Acclimatization Alleles Arctic Regions Body Height Body Weight Chromosomes Human Pair 11 Climate Diet High-Fat Fatty Acids Omega-3 Female Genetic Loci Genome Genome-Wide Association Study Greenland Humans Inuits Linkage Disequilibrium Male Membrane Lipids Polymorphism Single Nucleotide Selection Genetic Fumagalli, M Moltke, I Grarup, N Racimo, F Bjerregaard, P Jørgensen, ME Korneliussen, TS Gerbault, P Skotte, L Linneberg, A Christensen, C Brandslund, I Jørgensen, T Huerta-Sánchez, E Schmidt, EB Pedersen, O Hansen, T Albrechtsen, A Nielsen, R Greenlandic Inuit show genetic signatures of diet and climate adaptation. |
topic_facet |
Acclimatization Alleles Arctic Regions Body Height Body Weight Chromosomes Human Pair 11 Climate Diet High-Fat Fatty Acids Omega-3 Female Genetic Loci Genome Genome-Wide Association Study Greenland Humans Inuits Linkage Disequilibrium Male Membrane Lipids Polymorphism Single Nucleotide Selection Genetic |
description |
The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs. |
format |
Article in Journal/Newspaper |
author |
Fumagalli, M Moltke, I Grarup, N Racimo, F Bjerregaard, P Jørgensen, ME Korneliussen, TS Gerbault, P Skotte, L Linneberg, A Christensen, C Brandslund, I Jørgensen, T Huerta-Sánchez, E Schmidt, EB Pedersen, O Hansen, T Albrechtsen, A Nielsen, R |
author_facet |
Fumagalli, M Moltke, I Grarup, N Racimo, F Bjerregaard, P Jørgensen, ME Korneliussen, TS Gerbault, P Skotte, L Linneberg, A Christensen, C Brandslund, I Jørgensen, T Huerta-Sánchez, E Schmidt, EB Pedersen, O Hansen, T Albrechtsen, A Nielsen, R |
author_sort |
Fumagalli, M |
title |
Greenlandic Inuit show genetic signatures of diet and climate adaptation. |
title_short |
Greenlandic Inuit show genetic signatures of diet and climate adaptation. |
title_full |
Greenlandic Inuit show genetic signatures of diet and climate adaptation. |
title_fullStr |
Greenlandic Inuit show genetic signatures of diet and climate adaptation. |
title_full_unstemmed |
Greenlandic Inuit show genetic signatures of diet and climate adaptation. |
title_sort |
greenlandic inuit show genetic signatures of diet and climate adaptation. |
publishDate |
2015 |
url |
http://discovery.ucl.ac.uk/1487325/ |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland greenlandic inuit inuits |
genre_facet |
Arctic Greenland greenlandic inuit inuits |
op_source |
Science , 349 (6254) pp. 1343-1347. (2015) |
_version_ |
1766328293083054080 |