The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

Objective: The aim of this review is to clarify the involvement of the insulinlike growth factor (IGF) system in the development of colorectal malignancy. Materials and methods: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. Res...

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Bibliographic Details
Main Authors: Davies, M, Gupta, S, Goldspink, G, Winslet, M
Format: Article in Journal/Newspaper
Language:unknown
Published: SPRINGER 2006
Subjects:
FACTOR-I RECEPTOR
HUMAN COLON-CANCER
FACTOR-BINDING-PROTEINS
NECROSIS-FACTOR-ALPHA
IGF-I
FACTOR BINDING-PROTEIN-3
CHROMOSOME FRAGILITY
FACTOR EXPRESSION
NORTHERN SWEDEN
BREAST-CANCER
Northern Sweden
Online Access:http://discovery.ucl.ac.uk/1315682/
Description
Summary:Objective: The aim of this review is to clarify the involvement of the insulinlike growth factor (IGF) system in the development of colorectal malignancy. Materials and methods: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. Results: The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources. Conclusion: Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

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