Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies

INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD). METHODS: We performed an individual participant data meta-analysis using u...

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Bibliographic Details
Main Authors: van der Heide, Frank CT, Khawaja, Anthony, Berendschot, Tos TJM, Littlejohns, Thomas J, Kuźma, Elżbieta, Luben, Robert, Patel, Praveen J, Foster, Paul J, Maastricht Study, Consortium, Bertelsen, Geir, von Hanno, Therese, Johnsen, Bente, Schirmer, Henrik, Rebouças, Sara CL, Grasset, Leslie, Delcourt, Cécile, Helmer, Catherine, UK Biobank Eye & Vision, Consortium, E3, Consortium, Stehouwer, Coen DA
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2023
Subjects:
Alzheimer's disease
E3 consortium
OCT
The Alienor Study
The Maastricht Study
The Tromsø Study
The UK Biobank
UK Biobank Eye & Vision Consortium
dementia
early-onset dementia cohort
epidemiology
frontotemporal dementia
optical coherence tomography
retinal imaging
retinal neurodegeneration
vascular dementia
Tromsø
Online Access:https://discovery.ucl.ac.uk/id/eprint/10175526/1/Alzheimer%20s%20%20%20Dementia%20-%202023%20-%20Heide.pdf
https://discovery.ucl.ac.uk/id/eprint/10175526/
Description
Summary:INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD). METHODS: We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years). RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes. DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.

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