Lipase-Induced Oxidative Furan Rearrangements

Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of...

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Bibliographic Details
Main Authors: Blume, Fabian, Sprengart, Petra, Deska, Jan
Format: Article in Journal/Newspaper
Language:English
Published: GEORG THIEME VERLAG KG 2018
Subjects:
ddc:no
Antarc*
Antarctica
Online Access:https://kups.ub.uni-koeln.de/18534/
Description
Summary:Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of N-protected furfurylamines.

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