Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates
Prechter A, Gröger H, Heinrich MR. Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry . 2012;10(17): 3384. The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated us...
| Published in: | Organic & Biomolecular Chemistry |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Royal Society of Chemistry (RSC)
2012
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| Subjects: | |
| Online Access: | https://pub.uni-bielefeld.de/record/2490875 |
| Summary: | Prechter A, Gröger H, Heinrich MR. Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry . 2012;10(17): 3384. The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine. |
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