Genome-wide association analysis identifies three psoriasis susceptibility loci.

• Published in: Nature Genetics
• Main Authors: Stuart, PE, Nair, RP, Ellinghaus, E, Ding, J, Tejasvi, T, Gudjonsson, JE, Li, Y, Weidinger, S, Eberlein, B, Gieger, C, Wichmann, HE, Kunz, M, Ike, R, Krueger, GG, Bowcock, AM, Mrowietz, U, Lim, HW, Voorhees, JJ, Abecasis, GR, Weichenthal, M, Franke, A, Rahman, P, Gladman, DD, Elder, JT
• Other Authors: Klinik und Poliklinik für Dermatologie und Allergologie
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2010
• Subjects: info:eu-repo/classification/ddc/; Newfoundland
• Online Access: https://mediatum.ub.tum.de/1072983; https://doi.org/10.1038/ng.693

We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4 × 10?¹¹), one at FBXL19 (rs10782001, combined P = 9 × 10?¹?) and one near PSMA6-NFKBIA (rs12586317, combined P = 2 × 10??). All three loci were also associated with psoriatic arthritis (rs4795067, combined P = 1 × 10??; rs10782001, combined P = 4 × 10??; and rs12586317, combined P = 6 × 1??) and purely cutaneous psoriasis (rs4795067, combined P = 1 × 10??; rs10782001, combined P = 2 × 10??; and rs12586317, combined P = 1 × 10??). We also replicated a recently identified association signal near RNF114 (rs495337, combined P = 2 × 10??).