Environmental risk characteristics of bacterial antibiotic resistome in Antarctic krill

Antibiotic resistance genes (ARGs) are ubiquitous in nature, especially in the current era of antibiotic abuse, and their existence is a global concern. In the present study, we discovered that Antarctic krill-related culturable bacteria are resistant to β-lactam, tetracyclines, aminoglycosides, and...

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Bibliographic Details
Published in:Ecotoxicology and Environmental Safety
Main Authors: Yuanyuan Wang, Lingbo Ma, Jian He, Zhili He, Muhua Wang, Zixuan Liu, Zhimin Li, Lumin Wang, Shaoping Weng, Changjun Guo, Jianguo He
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2022
Subjects:
Antarctica
Antibiotic resistance genes
Antarctic krill
Ecological risks
geo
envir
Antarctic
Antarc*
Antarctic Krill
Online Access:https://doi.org/10.1016/j.ecoenv.2022.113289
https://doaj.org/article/b874330e47aa41658e2029cf4e5b49e0
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Summary:Antibiotic resistance genes (ARGs) are ubiquitous in nature, especially in the current era of antibiotic abuse, and their existence is a global concern. In the present study, we discovered that Antarctic krill-related culturable bacteria are resistant to β-lactam, tetracyclines, aminoglycosides, and sulphamethoxazole/trimethoprim based on the antibiotic efflux mechanism. In addition, the co-occurrence of ARGs with insertion sequence (IS) (tnpA, IS91) and Intl1 on the isolates and the phylogenetic analysis results of the whole-genome revealed low-frequency ARG transfer events, implying the transferability of these ARGs. These findings provide an early warning for the wide assessment of Antarctic microbiota in the spread of ARGs. Our work provides novel insights into understanding ARGs in culturable host-associated microorganisms, and their ecological risks and has important implications for future risk assessments of antibiotic resistance in extreme environments.

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