Common Genomic Variation in LMNA Modulates Indexes of Obesity in Inuit

"We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variati...

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Bibliographic Details
Main Authors: Hegele, Robert A., Huff, Murray W., Young, T. Kue
Format: Other/Unknown Material
Language:English
Published: 2001
Subjects:
psy
geo
inuit
Online Access:https://doi.org/10.7939/r3-jm95-e603
https://era.library.ualberta.ca/items/0facac93-bd4b-4a59-8640-726916ebbfd7
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Summary:"We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We subsequently discovered a common single nucleotide polymorphism (SNP) in LMNA, namely 1908C/T, which was associated with obesity-related traits in Canadian Oji-Cree." (as cited in abstract)

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