Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders

"Objectives: We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders. Study Design: Genetic association study of quantitative lipoprotein traits. Methods: In a sample of 1,...

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Bibliographic Details
Main Authors: Lahiry, Piya, Ban, Matthew R., Pollex, Rebecca L., Sawyez, Cynthia G., Huff, Murray W., Young, T. Kue, Bjerregaard, Peter, Hegele, Robert A.
Format: Other/Unknown Material
Language:English
Published: 2007
Subjects:
envir
socio
greenlander*
Online Access:https://doi.org/10.7939/r3-c2j6-a920
https://era.library.ualberta.ca/items/c552bc72-4a98-4b18-a8ed-6b3d242b531f
Description
Summary:"Objectives: We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders. Study Design: Genetic association study of quantitative lipoprotein traits. Methods: In a sample of 1,310 adult Greenlanders, fasting plasma lipid, lipoprotein and apolipoprotein (apo) concentrations were assessed for association with known functional genomic variants of APOC3, APOA5, APOE and PON1. For significantly associated polymorphisms, between-genotype differences were examined in closer detail." (as cited in abstract)

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