Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration

• Published in: European Journal of Epidemiology
• Language: English
• Published: Springer Netherlands 2012
• Subjects: Genetic; Risk prediction; Methodology; Guidelines; Reporting; Canada; Chapel Hill; Dowling; Grimshaw; Jeremy; Iceland
• Online Access: http://hdl.handle.net/2262/62766; https://doi.org/10.1007/s10654-011-9551-z

Abstract The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality. Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines. These recommendations aim to enhance the transparency, quality and completeness of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis. phone: [phone] (Janssens, A. Cecile J. W.) [e-mail] (Janssens, A. Cecile J. W.) Department of Epidemiology, Erasmus University Medical Center - PO Box 2040 - 3000 CA - Rotterdam - NETHERLANDS (Janssens, A. Cecile J. W.) Department of Hygiene and Epidemiology, University of Ioannina School of Medicine - Ioannina - GREECE (Ioannidis, John P. A.) Biomedical Research Institute, Foundation for Research and Technology - Ioannina - GREECE (Ioannidis, John P. A.) Department of Medicine, Tufts University School of Medicine - Boston - UNITED STATES (Ioannidis, John P. A.) Center for Genetic Epidemiology and Modeling and Tufts CTSI, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center - Boston - UNITED STATES (Ioannidis, John P. A.) Stanford Prevention Research Center, Stanford University School of Medicine - Stanford - UNITED STATES (Ioannidis, John P. A.) Office of Public Health Genomics, Centers for Disease Control and Prevention - Atlanta - UNITED STATES (Bedrosian, Sara) The Tisch Cancer Institute, Mount Sinai School of Medicine - New York - UNITED STATES (Boffetta, Paolo) International Prevention Research Institute - Lyon - FRANCE (Boffetta, Paolo) Department of Obstetrics & Gynecology and Women?s Health, Albert Einstein College of Medicine, Montefiore Medical Center - Bronx - UNITED STATES (Dolan, Siobhan M.) Office of Public Health Genomics, Centers for Disease Control and Prevention - Atlanta - UNITED STATES (Dowling, Nicole) Public Population Project in Genomics (P3G) - Montreal - CANADA (Fortier, Isabel) Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health - Bethesda - UNITED STATES (Freedman, Andrew N.) Clinical Epidemiology Program, Ottawa Hospital Research Institute - Ottawa - CANADA (Grimshaw, Jeremy M.) Department of Medicine, University of Ottawa - Ottawa - CANADA (Grimshaw, Jeremy M.) deCODE Genetics - Reykjavik - ICELAND (Gulcher, Jeffrey) Office of Public Health Genomics, Centers for Disease Control and Prevention - Atlanta - UNITED STATES (Gwinn, Marta) Department of Health Research and Policy, Stanford University - Palo Alto - UNITED STATES (Hlatky, Mark A.) Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Institute and Division of Public Health Sciences - Seattle - UNITED STATES (Janes, Holly) Department of Epidemiology, Harvard School of Public Health - Boston - UNITED STATES (Kraft, Peter) Office of Public Health Genomics, Centers for Disease Control and Prevention - Atlanta - UNITED STATES (Melillo, Stephanie) National Heart, Lung and Blood Institute (NHLBI) and the NHLBI?s Framingham Heart Study - Framingham - UNITED STATES (O?Donnell, Christopher J.) Cardiology Division, Massachusetts General Hospital, Harvard Medical School - Boston - UNITED STATES (O?Donnell, Christopher J.) Department of Biostatistics, Boston University - Boston - UNITED STATES (Pencina, Michael J.) Harvard Clinical Research Institute - Boston - UNITED STATES (Pencina, Michael J.) University of North Carolina at Chapel Hill School of Medicine - Chapel Hill - UNITED STATES (Ransohoff, David) Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health - Bethesda - UNITED STATES (Schully, Sheri D.) Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health - Bethesda - UNITED STATES (Seminara, Daniela) Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health - Bethesda - UNITED STATES (Winn, Deborah M.) PHG Foundation - Cambridge - UNITED KINGDOM (Wright, Caroline F.) Department of Epidemiology, Erasmus University Medical Center - PO Box 2040 - 3000 CA - Rotterdam - NETHERLANDS (Duijn, Cornelia M.) Department of Epidemiology and Community Medicine, University of Ottawa - Ottawa - CANADA (Little, Julian) Office of Public Health Genomics, Centers for Disease Control and Prevention - Atlanta - UNITED STATES (Khoury, Muin J.) CANADA FRANCE GREECE ICELAND NETHERLANDS UNITED KINGDOM UNITED STATES Registration: 2011-02-02 ePublished: 2011-03-22