Effects of Intralesional Triamcinalone Injection following Internal Urethrotomy for treatment of Stricture Urethra: A Prospective Analytical Experimental study
INTRODUCTION : stricture disease of urethra is always a challenge for almost all practicing urologists. Treatment optins available such as dilatation, DVIU , placement of stent, single or various stages of urethroplasty. Management by endoscopy is routinely done first for short bulbar urethral stric...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | http://repository-tnmgrmu.ac.in/2574/ http://repository-tnmgrmu.ac.in/2574/1/180400214rajarajan.pdf |
| Summary: | INTRODUCTION : stricture disease of urethra is always a challenge for almost all practicing urologists. Treatment optins available such as dilatation, DVIU , placement of stent, single or various stages of urethroplasty. Management by endoscopy is routinely done first for short bulbar urethral strictures before other modality of treatment. The reported success rate of single DVIU is 20 to 60 %. DVIU don’t produce epithelial approximation but it separates scarred epithelium so ,wound heals by secondry intention. If wound contraction takes place before full epithelialisation, it significantly narrows lumen and result in recurrence. Injection of steroid triamcinalone intralesionally following internal urethrotomy , decrease formation of scar by enhancing endogenous production of collagenase and obviates scar formation. In our study we analysed the outcome of injection of steroid (triamcinalone)& urethral stricture recurrence after DVIU. We analysed time duration between VIU and urethral stricture disease recurrence. AIM OF THE STUDY : 1. To study the effect of triamcinalone acetate injected intralesionally in patients undergoing internal urethrotomy (DVIU) for anterior urethral strictures. 2. To collect short term data on the need for self calibration or dilatation and other adjuvant procedures in those patients in one year. MATERIALS AND METHODS : It is a prospective study conducted in our institution from January2013 to February 2014.After receiving ethical committee approval from our institution , around 50 patients with stricture of urethra who are symptomatic and presenting at our hospital were selected . This was a prospective experimental study. 50 patients of stricture urethra who are symptomatic ,presenting at our hospital were segregated into two groups 25 in each containing group.The experimental Group (D) were treated by cold knife internal urethrotomy with intralesional triamcinolone injection while the control group (C) treated with urethrotomy alone. Postoperative results were compared between ... |
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