Cytokine respons i relation til alder, køn, body mass index, Mycobakterie tuberkulose infektion og otitis media i Grønland:Cytokin respons hos Inuit i Grønland

• Published in: American Journal of Human Biology
• Main Authors: Nielsen, Nina Odgaard, Soborg, Bolette, Børresen, Malene, Andersson, Mikael, Koch, Anders
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2012
• Subjects: Cytokine responses; Inuit; chronic infection; BMI; overweight; obesity; whole blood culture; Greenland; Grønland; inuit; Maniitsoq
• Online Access: https://portal.findresearcher.sdu.dk/da/publications/ff804c89-eb22-41f0-bc53-f07a26f2c612; https://doi.org/10.1002/ajhb.22332

Objectives: To evaluate the general cytokine responsiveness in Inuit in Greenland and examine the association between stimulated cytokine responses, chronic infections (Mycobacterium tuberculosis infection (MTI) and chronic otitis media (COM)) and BMI. Methods: A cross sectional health assessment was conducted among inhabitants of Maniitsoq, West Greenland, in 2009 and several health outcomes measured. The prevalence of MTI, overweight and obesity was assessed among 385 school children and 243 adults, and COM was assessed among the children. Cytokine responses were measured in whole blood from a subsample of participants (263 children and 137 adults) after stimulation with phytohaemagluttinin (PHA) or purified protein derivative (PPD). Associations between cytokine concentrations, chronic infections and BMI were estimated by linear regression. Results: The prevalence of MTI, COM, overweight and obesity was high among study participants. Children with MTI had 2.7 times higher IL-10 concentrations than those without (P=0.01), and girls had 80 % higher IL-10 than boys (P<0.01) after PHA stimulation. IFNγ and TNF concentrations were strongly elevated among children (PIFNγ<0.001 and PTNF<0.001) and adults (PIFNγ<0.001 and PTNF<0.01) with MTI compared to those without after PPD stimulation. Adult women had significantly lower IFNγ (P=0.03) and TNF (P=0.04) concentrations than men. TNF was positively correlated with BMI in children (P=0.01), and IL-10 was positively correlated with BMI in adults (P=0.0004) after PPD stimulation. Conclusion: We found cytokine patterns similar to those reported from other immune competent study populations. The study does therefore not support the suggestion that Inuit may have impaired immune reactivity to infection. To evaluate the cytokine response pattern in Inuit in Greenland in relation to age, gender, body mass index (BMI), Mycobacterium tuberculosis infection (MTI), and otitis media (OM) to assess whether Inuit may have signs of impaired immune responsiveness to ...