Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women

To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes.

Bibliographic Details
Published in:European Journal of Clinical Pharmacology
Main Authors: Kjærstad, Mia Birkhøj, Nielsen, Flemming, Nøhr-Jensen, Lene, Zwisler, Stine, Brøsen, Kim, Andersen, Helle Raun
Format: Article in Journal/Newspaper
Language:English
Published: 2010
Subjects:
CYP1A2
Caffeine
N3-demethylation
caffeine metobolic ratio
Polychlorinated Biphenyls
Faroe Islands
Online Access:https://portal.findresearcher.sdu.dk/da/publications/b26e0996-ebc7-43e2-b414-a97ec01b946c
https://doi.org/10.1007/s00228-010-0906-2
https://hal.archives-ouvertes.fr/hal-00629462/document
id ftsydanskunivpub:oai:sdu.dk:publications/b26e0996-ebc7-43e2-b414-a97ec01b946c
record_format openpolar
spelling ftsydanskunivpub:oai:sdu.dk:publications/b26e0996-ebc7-43e2-b414-a97ec01b946c 2024-04-28T08:18:20+00:00 Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women Kjærstad, Mia Birkhøj Nielsen, Flemming Nøhr-Jensen, Lene Zwisler, Stine Brøsen, Kim Andersen, Helle Raun 2010 https://portal.findresearcher.sdu.dk/da/publications/b26e0996-ebc7-43e2-b414-a97ec01b946c https://doi.org/10.1007/s00228-010-0906-2 https://hal.archives-ouvertes.fr/hal-00629462/document eng eng https://portal.findresearcher.sdu.dk/da/publications/b26e0996-ebc7-43e2-b414-a97ec01b946c info:eu-repo/semantics/restrictedAccess Kjærstad , M B , Nielsen , F , Nøhr-Jensen , L , Zwisler , S , Brøsen , K & Andersen , H R 2010 , ' Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women ' , European Journal of Clinical Pharmacology , vol. 66 , no. 12 , pp. 1189-97 . https://doi.org/10.1007/s00228-010-0906-2 CYP1A2 Caffeine N3-demethylation caffeine metobolic ratio Polychlorinated Biphenyls Faroe Islands article 2010 ftsydanskunivpub https://doi.org/10.1007/s00228-010-0906-2 2024-04-03T14:48:54Z To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal European Journal of Clinical Pharmacology 66 12 1189 1197
institution Open Polar
collection University of Southern Denmark Research Portal
op_collection_id ftsydanskunivpub
language English
topic CYP1A2
Caffeine
N3-demethylation
caffeine metobolic ratio
Polychlorinated Biphenyls
Faroe Islands
spellingShingle CYP1A2
Caffeine
N3-demethylation
caffeine metobolic ratio
Polychlorinated Biphenyls
Faroe Islands
Kjærstad, Mia Birkhøj
Nielsen, Flemming
Nøhr-Jensen, Lene
Zwisler, Stine
Brøsen, Kim
Andersen, Helle Raun
Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women
topic_facet CYP1A2
Caffeine
N3-demethylation
caffeine metobolic ratio
Polychlorinated Biphenyls
Faroe Islands
description To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes.
format Article in Journal/Newspaper
author Kjærstad, Mia Birkhøj
Nielsen, Flemming
Nøhr-Jensen, Lene
Zwisler, Stine
Brøsen, Kim
Andersen, Helle Raun
author_facet Kjærstad, Mia Birkhøj
Nielsen, Flemming
Nøhr-Jensen, Lene
Zwisler, Stine
Brøsen, Kim
Andersen, Helle Raun
author_sort Kjærstad, Mia Birkhøj
title Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women
title_short Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women
title_full Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women
title_fullStr Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women
title_full_unstemmed Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women
title_sort systemic uptake of miconazole during vaginal suppository use and effect on cyp1a2 and cyp3a4 associated enzyme activities in women
publishDate 2010
url https://portal.findresearcher.sdu.dk/da/publications/b26e0996-ebc7-43e2-b414-a97ec01b946c
https://doi.org/10.1007/s00228-010-0906-2
https://hal.archives-ouvertes.fr/hal-00629462/document
genre Faroe Islands
genre_facet Faroe Islands
op_source Kjærstad , M B , Nielsen , F , Nøhr-Jensen , L , Zwisler , S , Brøsen , K & Andersen , H R 2010 , ' Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women ' , European Journal of Clinical Pharmacology , vol. 66 , no. 12 , pp. 1189-97 . https://doi.org/10.1007/s00228-010-0906-2
op_relation https://portal.findresearcher.sdu.dk/da/publications/b26e0996-ebc7-43e2-b414-a97ec01b946c
op_rights info:eu-repo/semantics/restrictedAccess
op_doi https://doi.org/10.1007/s00228-010-0906-2
container_title European Journal of Clinical Pharmacology
container_volume 66
container_issue 12
container_start_page 1189
op_container_end_page 1197
_version_ 1797582397267509248

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