Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women

To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes.

Bibliographic Details
Published in:	European Journal of Clinical Pharmacology
Main Authors:	Kjærstad, Mia Birkhøj, Nielsen, Flemming, Nøhr-Jensen, Lene, Zwisler, Stine, Brøsen, Kim, Andersen, Helle Raun
Format:	Article in Journal/Newspaper
Language:	English
Published:	2010
Subjects:	CYP1A2 Caffeine N3-demethylation caffeine metobolic ratio Polychlorinated Biphenyls Faroe Islands
Online Access:	https://portal.findresearcher.sdu.dk/da/publications/b26e0996-ebc7-43e2-b414-a97ec01b946c https://doi.org/10.1007/s00228-010-0906-2 https://hal.archives-ouvertes.fr/hal-00629462/document

Description
Summary:	To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes.