Are TMEM genes potential candidate genes for panic disorder?

We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously...

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Bibliographic Details
Published in:Psychiatric Genetics
Main Authors: Gregersen, Noomi O, Buttenschøn, Henriette N, Hedemand, Anne, Dahl, Hans A, Kristensen, Ann S, Clementsen, Birita, Woldbye, David P D, Koefoed, Pernille, Erhardt, Angelika, Kruse, Torben A, Wang, August G, Børglum, Anders D, Mors, Ole
Format: Article in Journal/Newspaper
Language:English
Published: 2014
Subjects:
Case-Control Studies
Chromosomes
Human
Pair 17
Humans
Membrane Proteins
Panic Disorder
Polymorphism
Single Nucleotide
Faroe Islands
Online Access:https://portal.findresearcher.sdu.dk/da/publications/a4852560-cdd9-4637-923f-87a488f900ed
https://doi.org/10.1097/YPG.0000000000000022
Description
Summary:We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.

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