Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. A...

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Bibliographic Details
Published in:Eurosurveillance
Main Authors: Agergaard, Charlotte Nielsen, Porsbo, Lone Jannok, Sydenham, Thomas Vognbjerg, Hansen, Sanne Grønvall Kjær, Steinke, Kat, Larsen, Sanne Løkkegaard, Helgason, Kristján Orri, Hansen, Frank, Karstensen, Kasper Thystrup, Henius, Anna E., Holzknecht, Barbara Juliane, Søes, Lillian, Schønning, Kristian, Wang, Mikala, Ank, Nina, Halldórsdóttir, Anna Margrét, Guðlaugsson, Ólafur, Hammerum, Anette M., Kjerulf, Anne, Kristensen, Brian, Hasman, Henrik, Justesen, Ulrik Stenz
Format: Article in Journal/Newspaper
Language:English
Published: 2023
Subjects:
antibiotic
CPO
dicloxacillin
Enterobacter hormaechei
Outbreak
Iceland
Online Access:https://portal.findresearcher.sdu.dk/da/publications/893a484c-b7e1-49f6-b4f0-8b56034f72b7
https://doi.org/10.2807/1560-7917.ES.2023.28.9.2300108
https://findresearcher.sdu.dk/ws/files/224383876/eurosurv_28_9_1.pdf
Description
Summary:From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.

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