Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides

Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively...

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Bibliographic Details
Published in:Nucleosides, Nucleotides and Nucleic Acids
Main Authors: Prasad, A. K., Singh, S. K., Kalra, Neerja, Singhal, N., Wengel, Jesper, Parmar, Virinder S.
Format: Article in Journal/Newspaper
Language:English
Published: 2007
Subjects:
Antarc*
Antarctica
Online Access:https://portal.findresearcher.sdu.dk/da/publications/36ffb520-dfb3-11dc-a57f-000ea68e967b
https://doi.org/10.1080/15257770701544302
Description
Summary:Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively in a highly selective and efficient manner.

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