Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides
Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively...
Published in: | Nucleosides, Nucleotides and Nucleic Acids |
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Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2007
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Subjects: | |
Online Access: | https://portal.findresearcher.sdu.dk/da/publications/36ffb520-dfb3-11dc-a57f-000ea68e967b https://doi.org/10.1080/15257770701544302 |
Summary: | Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively in a highly selective and efficient manner. |
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