Design of a Pd(0)-CalB CLEA Biohybrid Catalyst and Its Application in a One-Pot Cascade Reaction

Herein, a design of a biohybrid catalyst is described, consisting of Pd nanoparticles and a cross-linked network of aggregated lipase B enzyme of Candida antarctica (CalB CLEA) functioning as an active support for the Pd nanoparticles. Both entities of the hybrid catalyst showed good catalytic activ...

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Bibliographic Details
Published in:ACS Catalysis
Main Authors: Görbe, Tamás, Gustafson, Karl P. J., Verho, Oscar, Kervefors, Gabriella, Zheng, Haoquan, Zou, Xiaodong, Johnston, Eric V., Bäckvall, Jan-E.
Format: Article in Journal/Newspaper
Language:English
Published: Stockholms universitet, Institutionen för organisk kemi 2017
Subjects:
kinetic resolution
biohybrid catalyst
Pd nanoparticles
CalB
cycloisomerization
one-pot cascade reaction
Organic Chemistry
Organisk kemi
Antarc*
Antarctica
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142484
https://doi.org/10.1021/acscatal.6b03481
Description
Summary:Herein, a design of a biohybrid catalyst is described, consisting of Pd nanoparticles and a cross-linked network of aggregated lipase B enzyme of Candida antarctica (CalB CLEA) functioning as an active support for the Pd nanoparticles. Both entities of the hybrid catalyst showed good catalytic activity. The applicability was demonstrated in a one-pot reaction, where the Pd-catalyzed cycloisomerization of 4-pentynoic acid afforded a lactone that serves as an acyl donor in a subsequent selective enzymatic kinetic resolution of a set of sec-alcohols. The catalyst proved to be robust and could be recycled five times without a significant loss of activity.

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