Trends in incidence of thick, thin and in situ melanoma in Europe.

We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995-2012, stratifying for lesion thickness. Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including in...

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Bibliographic Details
Published in:European Journal of Cancer
Main Authors: Sacchetto, L, Zanetti, R, Comber, H, Bouchardy, C, Brewster, D H, Broganelli, P, Chirlaque, M D, Coza, D, Galceran, J, Gavin, A, Hackl, M, Katalinic, A, Larønningen, S, Louwman, M W J, Morgan, E, Robsahm, T E, Sanchez, M J, Tryggvadóttir, L, Tumino, R, Van Eycken, E, Vernon, S, Zadnik, V, Rosso, S
Format: Article in Journal/Newspaper
Language:English
Published: 2018
Subjects:
Breslow
Melanoma incidence trends
Melanoma mortality trends
Thickness
Thin lesions
Age Distribution
Databases
Factual
Europe
Female
Humans
Incidence
Male
Melanoma
Middle Aged
Mortality
Neoplasm Invasiveness
Registries
Sex Distribution
Skin Neoplasms
Time Factors
Norway
Iceland
Online Access:http://hdl.handle.net/10668/12080
https://doi.org/10.1016/j.ejca.2017.12.024
https://archive-ouverte.unige.ch/unige:115935/ATTACHMENT01
Description
Summary:We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995-2012, stratifying for lesion thickness. Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including information on age, sex, year of diagnosis, histological type, tumour location, behaviour (invasive, in situ) and lesion thickness. Mortality data were retrieved from the publicly available World Health Organization database. Our database covered a population of over 117 million inhabitants and included about 415,000 skin lesions, recorded by 18 European CRs (7 of them with national coverage). During the 1995-2012 period, we observed a statistically significant increase in incidence for both invasive (average annual percent change (AAPC) 4.0% men; 3.0% women) and in situ (AAPC 7.7% men; 6.2% women) cases. The increase in invasive lesions seemed mainly driven by thin melanomas (AAPC 10% men; 8.3% women). The incidence of thick melanomas also increased, although more slowly in recent years. Correction for lesions of unknown thickness enhanced the differences between thin and thick cases and flattened the trends. Incidence trends varied considerably across registries, but only Netherlands presented a marked increase above the boundaries of a funnel plot that weighted estimates by their precision. Mortality from invasive melanoma has continued to increase in Norway, Iceland (but only for elder people), the Netherlands and Slovenia.

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