Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200
Six new nonadride derivatives, named talarodrides A–F ( 1 – 6 ), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1 –...
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ftsmithonian:oai:figshare.com:article/17092085 2023-05-15T13:40:20+02:00 Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 Yi Zhao (14034) Chunxiao Sun (8633598) Luyao Huang (693708) Xiao Zhang (152326) Guojian Zhang (1604386) Qian Che (725671) Dehai Li (1433623) Tianjiao Zhu (1433617) 2021-11-29T00:00:00Z https://doi.org/10.1021/acs.jnatprod.1c00203.s001 unknown https://figshare.com/articles/journal_contribution/Talarodrides_A_F_Nonadrides_from_the_Antarctic_Sponge-Derived_Fungus_i_Talaromyces_i_sp_HDN1820200/17092085 doi:10.1021/acs.jnatprod.1c00203.s001 CC BY-NC 4.0 CC-BY-NC Biochemistry Pharmacology Inorganic Chemistry Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified rare caged bicyclo extensive spectroscopic analysis computational ecd calculations >] furan skeleton vibrio parahemolyticus </ proteus mirabilis </ naturally occurring 5 13 – 12 6 methanocyclonona [< 1 ]- deca 5 </ b 6 </ b 4 </ b talaromyces </ c </ 5 μm – f (< b structures including first case derived fungus bridgehead olefin antarctic sponge absolute configurations Text Journal contribution 2021 ftsmithonian https://doi.org/10.1021/acs.jnatprod.1c00203.s001 2021-12-19T19:27:00Z Six new nonadride derivatives, named talarodrides A–F ( 1 – 6 ), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1 – 4 share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds 5 and 6 possess the first case of a naturally occurring 5/7/6 methanocyclonona[ c ]furan skeleton. Talarodride A ( 1 ) and talarodride B ( 2 ) showed selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus with MICs of 3.13–12.5 μM. Other Non-Article Part of Journal/Newspaper Antarc* Antarctic Unknown Antarctic The Antarctic |
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op_collection_id |
ftsmithonian |
language |
unknown |
topic |
Biochemistry Pharmacology Inorganic Chemistry Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified rare caged bicyclo extensive spectroscopic analysis computational ecd calculations >] furan skeleton vibrio parahemolyticus </ proteus mirabilis </ naturally occurring 5 13 – 12 6 methanocyclonona [< 1 ]- deca 5 </ b 6 </ b 4 </ b talaromyces </ c </ 5 μm – f (< b structures including first case derived fungus bridgehead olefin antarctic sponge absolute configurations |
spellingShingle |
Biochemistry Pharmacology Inorganic Chemistry Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified rare caged bicyclo extensive spectroscopic analysis computational ecd calculations >] furan skeleton vibrio parahemolyticus </ proteus mirabilis </ naturally occurring 5 13 – 12 6 methanocyclonona [< 1 ]- deca 5 </ b 6 </ b 4 </ b talaromyces </ c </ 5 μm – f (< b structures including first case derived fungus bridgehead olefin antarctic sponge absolute configurations Yi Zhao (14034) Chunxiao Sun (8633598) Luyao Huang (693708) Xiao Zhang (152326) Guojian Zhang (1604386) Qian Che (725671) Dehai Li (1433623) Tianjiao Zhu (1433617) Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 |
topic_facet |
Biochemistry Pharmacology Inorganic Chemistry Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified rare caged bicyclo extensive spectroscopic analysis computational ecd calculations >] furan skeleton vibrio parahemolyticus </ proteus mirabilis </ naturally occurring 5 13 – 12 6 methanocyclonona [< 1 ]- deca 5 </ b 6 </ b 4 </ b talaromyces </ c </ 5 μm – f (< b structures including first case derived fungus bridgehead olefin antarctic sponge absolute configurations |
description |
Six new nonadride derivatives, named talarodrides A–F ( 1 – 6 ), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1 – 4 share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds 5 and 6 possess the first case of a naturally occurring 5/7/6 methanocyclonona[ c ]furan skeleton. Talarodride A ( 1 ) and talarodride B ( 2 ) showed selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus with MICs of 3.13–12.5 μM. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Yi Zhao (14034) Chunxiao Sun (8633598) Luyao Huang (693708) Xiao Zhang (152326) Guojian Zhang (1604386) Qian Che (725671) Dehai Li (1433623) Tianjiao Zhu (1433617) |
author_facet |
Yi Zhao (14034) Chunxiao Sun (8633598) Luyao Huang (693708) Xiao Zhang (152326) Guojian Zhang (1604386) Qian Che (725671) Dehai Li (1433623) Tianjiao Zhu (1433617) |
author_sort |
Yi Zhao (14034) |
title |
Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 |
title_short |
Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 |
title_full |
Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 |
title_fullStr |
Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 |
title_full_unstemmed |
Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200 |
title_sort |
talarodrides a–f, nonadrides from the antarctic sponge-derived fungus talaromyces sp. hdn1820200 |
publishDate |
2021 |
url |
https://doi.org/10.1021/acs.jnatprod.1c00203.s001 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
https://figshare.com/articles/journal_contribution/Talarodrides_A_F_Nonadrides_from_the_Antarctic_Sponge-Derived_Fungus_i_Talaromyces_i_sp_HDN1820200/17092085 doi:10.1021/acs.jnatprod.1c00203.s001 |
op_rights |
CC BY-NC 4.0 |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1021/acs.jnatprod.1c00203.s001 |
_version_ |
1766132463479816192 |