Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200

• Main Authors: Yi Zhao (14034), Chunxiao Sun (8633598), Luyao Huang (693708), Xiao Zhang (152326), Guojian Zhang (1604386), Qian Che (725671), Dehai Li (1433623), Tianjiao Zhu (1433617)
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: 2021
• Subjects: Biochemistry; Pharmacology; Inorganic Chemistry; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; rare caged bicyclo; extensive spectroscopic analysis; computational ecd calculations; >]­ furan skeleton; vibrio parahemolyticus </; proteus mirabilis </; naturally occurring 5; 13 – 12; 6 methanocyclonona ­[<; 1 ]- deca; 5 </ b; 6 </ b; 4 </ b; talaromyces </; c </; 5 μm; – f; (< b; structures including; first case; derived fungus; bridgehead olefin; antarctic sponge; absolute configurations; Antarctic; The Antarctic; Antarc*
• Online Access: https://doi.org/10.1021/acs.jnatprod.1c00203.s001

Six new nonadride derivatives, named talarodrides A–F ( 1 – 6 ), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1 – 4 share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds 5 and 6 possess the first case of a naturally occurring 5/7/6 methanocyclonona­[ c ]­furan skeleton. Talarodride A ( 1 ) and talarodride B ( 2 ) showed selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus with MICs of 3.13–12.5 μM.