Comparison of genes under selection based on pN/pS ratios for each sampling region.

• Main Authors: Tristan M. Baecklund (10573715), Michael E. Donaldson (4431115), Karsten Hueffer (606200), Christopher J. Kyle (8136867)
• Format: Dataset
• Language: unknown
• Published: 2021
• Subjects: Genetics; Evolutionary Biology; Ecology; Infectious Diseases; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; somewhat unexpected given; rapidly changing environments; north american range; necessarily reflect causation; corroborating past research; undermine local adaptation; local adaptation enhance; contrasting genetic structure; mediate host responses; provide data relevant; div >< p; neutral genetic structure; arctic rabies variants; local adaptation; genetic structure; neutral loci; primary host; natural host; host populations; traits expected; sequencing assay; sampled regions; remains unknown; outliers associated; northern climates; lived nature; largely persists; increased frequencies; geographic distributions; foxes predominated; evolutionary relationships; dispersal capacities; direct link; differential selection; data contribute; assessed correlations; arctic rabies; arctic fox; advantageous genotypes; Arctic; Rozas; Arctic Fox
• Online Access: https://doi.org/10.1371/journal.pone.0258975.s016

For each gene highlights the ratio of non-synonymous substitutions per non-synonymous site (pN) to synonymous substitutions per synonymous site (pS) across the three sampled regions, as well as a test of significance using the Chi squared p-values. Bolded ratios indicated those pN/pS ratios greater than or equal to 1 suggestive of directional selection and those pN/pS ratios that have statistically significant p values. Polymorphic sites were determined using SnpEff and potential nonsynonymous/synonymous sites were determined using the coding sequence for each gene as input for DnaSP v6. (Rozas et al. 2017 [ 68 ]). (XLSX)