Nonconservative amino acid substitutions between marine mammals, cow, and mouse melanopsins (Opn4) within transmembrane domains.

Nonconservative amino acids substitutions (red; consensus residue: Position: Substitution) are as follows: Transmembrane region (TM) I: Thr89Met (walrus, manatee, polar bear); Thr93Iso (manatee); TMII: Ala123Thr (manatee); Ala128Thr (Yangtze river dolphin); TMIV: Ala187Thr (beluga whale, harbor porp...

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Bibliographic Details
Main Authors: Jeffry I. Fasick (3624569), Haya Algrain (11570761), Courtland Samuels (11570764), Padmanabhan Mahadevan (475388), Lorian E. Schweikert (3624572), Zaid J. Naffaa (11570767), Phyllis R. Robinson (204369)
Format: Still Image
Language:unknown
Published: 2021
Subjects:
Biochemistry
Cell Biology
Molecular Biology
Neuroscience
Evolutionary Biology
Ecology
Virology
Environmental Sciences not elsewhere classified
water &# 8217
serve light detection
retinal ganglion cells
carboxyl terminal domain
available light spectra
marine mammal rhodopsins
thus longer mydriasis
extended pupillary constriction
amino acid substitutions
marine mammal species
div >< p
marine mammals may
marine mammals
pupil constriction
mydriasis occurs
identify substitutions
given species
values tuned
values relative
terrestrial counterparts
terrestrial controls
spectral tuning
spectral sensitivity
solar irradiance
significant change
rod retina
rod monochromacy
results suggest
results show
previous work
prevent photobleaching
orders sirenia
likely involved
infraorder cetacea
highly photosensitive
foraging depths
deactivation kinetics
condition known
cdna sequences
absorbance maxima
Weddell
Beluga
Beluga whale
Beluga*
Weddell Seal
walrus*
Online Access:https://doi.org/10.1371/journal.pone.0257436.g003
Description
Summary:Nonconservative amino acids substitutions (red; consensus residue: Position: Substitution) are as follows: Transmembrane region (TM) I: Thr89Met (walrus, manatee, polar bear); Thr93Iso (manatee); TMII: Ala123Thr (manatee); Ala128Thr (Yangtze river dolphin); TMIV: Ala187Thr (beluga whale, harbor porpoise, Yangtze finless porpoise,); ECL II: Ala233Thr (manatee); ICL III: Glu295Ala (manatee and mouse); TMVI: Thr311Ala (Weddell seal); Val/Met315Thr (Weddell seal, walrus); TMVII: Tyr342His (Weddell seal, walrus, manatee, polar bear and mouse). Opn4 numbering is from mouse.

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