Gabadoxol (THIP) feeding induces sleep.

• Main Authors: Jenifer C. Kaldun (11530225), Shahnaz R. Lone (11530228), Ana M. Humbert Camps (11530231), Cornelia Fritsch (436027), Yves F. Widmer (11530234), Jens V. Stein (3154206), Seth M. Tomchik (9155250), Simon G. Sprecher (10058941)
• Format: Still Image
• Language: unknown
• Published: 2021
• Subjects: Cell Biology; Molecular Biology; Neuroscience; Mental Health; Biological Sciences not elsewhere classified; involved circuitry ameliorates; div >< p; >< sub ><; &# 946 ;</; modulate forgetting caused; regulating neuronal excitability; molecular disease pathways; drosophila melanogaster </; drosophila </; accelerates forgetting; neuronal expression; arctic </; 42 </; well understood; targeted expression; similar effects; related dementia; promising mechanism; pathological hallmark; olfactory memories; mushroom bodies; memory defects; main causes; fly brain; feeding levetiracetam; central component; alzheimer disease; ></ sup; Arctic
• Online Access: https://doi.org/10.1371/journal.pbio.3001412.s006

Related to Fig 4 . (A) Sleep profile of wild-type Canton-S flies that received different concentrations of THIP or the vehicle. (B) Sleep profile of OK107-Aβ 42 Arctic flies and parental controls on THIP (C) Quantification of daytime and nighttime sleep; daytime and nighttime sleep was significantly increased in flies that received 0.01, 0.06, or 0.33 mg/ml THIP (n ≥ 24), compared to control flies that received no THIP. (D) Arousal response of THIP-fed flies. At ZT18, a light pulse was used to wake the flies up. (E) Sleep profile of 8- to 10-day-old flies expressing Aβ Arctic in the MB. All other details are similar to Fig 1 . MB, mushroom body. (TIF)