Effect of LEV on sleep.

• Main Authors: Jenifer C. Kaldun (11530225), Shahnaz R. Lone (11530228), Ana M. Humbert Camps (11530231), Cornelia Fritsch (436027), Yves F. Widmer (11530234), Jens V. Stein (3154206), Seth M. Tomchik (9155250), Simon G. Sprecher (10058941)
• Format: Still Image
• Language: unknown
• Published: 2021
• Subjects: Cell Biology; Molecular Biology; Neuroscience; Mental Health; Biological Sciences not elsewhere classified; involved circuitry ameliorates; div >< p; >< sub ><; &# 946 ;</; modulate forgetting caused; regulating neuronal excitability; molecular disease pathways; drosophila melanogaster </; drosophila </; accelerates forgetting; neuronal expression; arctic </; 42 </; well understood; targeted expression; similar effects; related dementia; promising mechanism; pathological hallmark; olfactory memories; mushroom bodies; memory defects; main causes; fly brain; feeding levetiracetam; central component; alzheimer disease; ></ sup; Arctic
• Online Access: https://doi.org/10.1371/journal.pbio.3001412.s005

Related to Fig 2 . (A) Effect of LEV on the 2-h aversive memory of nSyb > Aβ 42 Arctic flies. The memory impairment is not rescued by LEV. (B) Amount of day and night time sleep of flies receiving different amounts of LEV. (C) Expression of the nonconducting K + -channel dORKΔNC or constitutive conducting dORKΔC in the MB of Aβ 42 Arctic -expressing flies. At 0 h after training, no significant difference is observed (n ≥ 8). (D, E) Memory performance of flies only expressing the dORK constructs 0 h (D) and 2 h (E) after training. (n ≥ 8). All other details are similar to Fig 1 . LEV, Levetiracetam; MB, mushroom body. (TIF)