Expression of amyloid β peptides in the DANs.

• Main Authors: Jenifer C. Kaldun (11530225), Shahnaz R. Lone (11530228), Ana M. Humbert Camps (11530231), Cornelia Fritsch (436027), Yves F. Widmer (11530234), Jens V. Stein (3154206), Seth M. Tomchik (9155250), Simon G. Sprecher (10058941)
• Format: Still Image
• Language: unknown
• Published: 2021
• Subjects: Cell Biology; Molecular Biology; Neuroscience; Mental Health; Biological Sciences not elsewhere classified; involved circuitry ameliorates; div >< p; >< sub ><; &# 946 ;</; modulate forgetting caused; regulating neuronal excitability; molecular disease pathways; drosophila melanogaster </; drosophila </; accelerates forgetting; neuronal expression; arctic </; 42 </; well understood; targeted expression; similar effects; related dementia; promising mechanism; pathological hallmark; olfactory memories; mushroom bodies; memory defects; main causes; fly brain; feeding levetiracetam; central component; alzheimer disease; ></ sup; Arctic
• Online Access: https://doi.org/10.1371/journal.pbio.3001412.s004

Related to Fig 1 . (A) Aversive olfactory conditioning experiment was conducted with Aβ 42 Arctic -expressing flies in most DANs. TH> Aβ 42 Arctic flies have a learning defect after training (n ≥ 12) (B) Appetitive olfactory conditioning with flies expressing Aβ 42 Arctic in the PAM cluster. PAM > Aβ 42 Arctic flies have a learning defect immediately after training (n ≥ 12). See S1 Table for the data. Bar graphs represent the mean, and error bars represent the standard error of the mean. Asterisks denote significant difference between groups (* p < 0.05, ** p < 0.005, *** p < 0.001). DAN, dopaminergic neuron. (TIF)