| Summary: | Related to Fig 1 . (A-C) Sensory tests of flies expressing Aβ 42 Arctic restricted to the adult stage with Elav GS alongside the parental controls. Flies were fed with either RU486 or the vehicle. (A) Odor avoidance test of MCH. (B) Odor avoidance test for 3-Oct. (C) Shock response test memory scores of the tested genotypes did not differ from each other. (D) 0-h aversive memory of flies expressing Aβ 42 Arctic in the adult brain using the Elav GS system. Flies were fed with either RU486 or the vehicle. (E) 0-h aversive memory of flies expressing Aβ 42 Arctic in the adult MB using the MB GS system. Flies were fed with either RU486 or the vehicle. (F) Memory performance 2 h after aversive training of 4- to 5-day-old OK107 > Aβ 42 Arctic flies and parental controls with no accelerated forgetting phenotype. (G) 14- to 15-day-old OK107 > Aβ 42 Arctic flies show a learning defect compared to parental controls. All other details are similar to Fig 1 . MB, mushroom body; MCH, 4-methyl-cyclohexanol; 3-Oct, 3-Octanol. (TIF)
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