| Summary: | Related to Fig 1 . (A-C) Sensory tests of flies expressing Aβ 42 Arctic pan-neuronally alongside the parental controls. (A) Odor avoidance test of MCH. (B) Odor avoidance test for 3-Oct. (C) Shock response test. (D) 2-h aversive memory of nSyb > Aβ 42 Arctic flies is significantly different to parental controls. (E-G) Sensory test of flies expressing Aβ 42 Arctic in the MB alongside the parental controls. (E) Odor avoidance test of MCH. (F) Odor avoidance test for 3-Oct. (G) Shock response test. (H) Memory assessment of flies expressing Aβ Arctic in the MB at different time points (0, 2, 4, and 6 h) after conditioning. The values for 0 h and 2 h are the same as in Fig 1C and 1D . (I) Flies were subjected to 2 min of cold shock treatment that erases the labile ASM component. Animals expressing Aβ 42 Arctic in the MB showed impaired 2-h memory after cold shock conditions (n ≥ 12). ASM, anesthesia-sensitive memory; MB, mushroom body; MCH, 4-methyl-cyclohexanol; 3-Oct, 3-Octanol. (TIF)
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