The differentially methylated loci (DML: |delta β|≥0.10; FDR <0.05) between ER- and ER+ tumors in AA and EA women.

• Main Authors: Zhihong Gong (448693), Jianhong Chen (1632946), Jie Wang (16762), Song Liu (9858), Christine B. Ambrosone (8954762), Michael J. Higgins (153782)
• Format: Still Image
• Language: unknown
• Published: 2021
• Subjects: Biophysics; Cell Biology; Genetics; Molecular Biology; Cancer; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; DNA methylation patterns; EA women; DNA methylation-dysregulated miRNAs; DML; EMT; FDR; ER; miRNA encoding genes; TCGA; American women; cell cycle G 1-S growth factor regu.; breast cancer subtypes; breast cancer; differentially methylated loci; European ancestry Aggressive; miRNA expression; genome-wide methylation screen; DNA methylation changes; AA; ESR; genome-wide DNA methylation-based m.; The ''Y''; Venn
• Online Access: https://doi.org/10.1371/journal.pone.0249229.g002

(A) Venn diagram showing the number of DMLs between ER- vs. ER+ tumor specific to EA women (n = 136), common in both AA and EA women (n = 290), and specific to AA women (n = 317). (B) The histogram shows the differences in proportions ( P <0.05) of hyper- and hypo- methylated by ER-DMLs in AA-specific, AA-EA Shared, and EA-specific groups. (C and D) Volcano plots showing distributions of hyper- and hypo- methylated DMLs between ER- vs. ER+ tumor in AA (C) and in EA women (D). Dots plotted in red represent DMLs specific to either AA or EA women; Dots plotted in blue represent DMLs shared in both AA and EA women; red or blue dots in the right panel represent for hypermethylated and those in the left panel for hypomethylated DMLs. Dots plotted in grey are not DMLs in either AA or EA women. The mean methylation difference (|delta β|) in ER- versus ER+ tumors is on the X axis, and the Y axis shows the log 10 of FDR (adjusted P -value).