Unsupervised consensus cluster analysis of miRNA methylation patterns of breast tissues.

Two major clusters were identified. Cluster 1 contains primarily ER+ breast tumors; cluster 2 is enriched for ER- tumors.

Bibliographic Details
Main Authors: Zhihong Gong (448693), Jianhong Chen (1632946), Jie Wang (16762), Song Liu (9858), Christine B. Ambrosone (8954762), Michael J. Higgins (153782)
Format: Still Image
Language:unknown
Published: 2021
Subjects:
Biophysics
Cell Biology
Genetics
Molecular Biology
Cancer
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
DNA methylation patterns
EA women
DNA methylation-dysregulated miRNAs
DML
EMT
FDR
ER
miRNA encoding genes
TCGA
American women
cell cycle G 1-S growth factor regu.
breast cancer subtypes
breast cancer
differentially methylated loci
European ancestry Aggressive
miRNA expression
genome-wide methylation screen
DNA methylation changes
AA
ESR
genome-wide DNA methylation-based m.
Online Access:https://doi.org/10.1371/journal.pone.0249229.g001
Description
Summary:Two major clusters were identified. Cluster 1 contains primarily ER+ breast tumors; cluster 2 is enriched for ER- tumors.

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